ABSTRACT
A spectrophotometric method and two titrimetric methods for the determination of clorazepate dipotassium via its Iodobismuthate complex are described. These methods depend on, the reaction of clorazepate dipotassium with potassium bismuth iodide which give an orange precipitate. Determination of clorazepate dipotassium in the precipitated complex is done iodometrically using standard potassium iodate solution or complexometrically using standard EDTA solution and xylenol orange indicator. Alternatively, the complex is dissolved in ethyl alcohol and its absorbance is measured at 322 nm. The three methods were successfully applied for the determination of authentic samples of clorazepate dipotassium in the concentration range of 5-25 mg [for the titrimetric method and 40-120 mcg [for the spectrophotometric method]. The mean percentage recoveries were found to be 99.61 +/- 0.81, 99.80 +/- 0.48 - and 99.97 +/- 0.50 for the three methods, respectively. The proposed methods described were successfully applied for the determination of clorazepate dipotassium in tranxene capsules and the validity of the suggested procedures was assessed by applying the standard addition technique