ABSTRACT
There is limited information regarding the efficacy of 'directly observed treatment short course' (DOTS) in the treatment of intestinal tuberculosis. We randomized patients with ileocecal or colonic tuberculosis to receive daily tuberculosis chemotherapy (Group A) or DOTS (Group B). Patients received isoniazid, rifampicin, pyrazinamide and ethambutol daily for two months in group A and thrice weekly for 2 months in group B, followed by isoniazid and rifampicin daily for 7 months in group A and thrice weekly for 4 months in group B. Patients were followed up at 2 and 4 weeks and monthly thereafter until the end of treatment. Follow up colonoscopy was done at 2 and 6 months after starting treatment. The improvement in clinical symptoms was not different between Groups A (24) and B (23) at 2 and 6 months. Mean increase in weight was 5.1 (0.5) Kg and 5.7 (0.6) Kg at 2 months and 7.1 (1.7) Kg and 6.9 (1.9) Kg at 6 months in Group A and B, respectively. Complete healing of ulceration was noted in 75% of Group A patients and 79% of Group B patients at 2 months and in all patients in both groups at 6 months. We conclude that DOTS and daily chemotherapy are equally effective for treating ileocecal and colonic tuberculosis.
Subject(s)
Antitubercular Agents/administration & dosage , Cecal Diseases/drug therapy , Colonic Diseases/drug therapy , Directly Observed Therapy , Ileal Diseases/drug therapy , Treatment Outcome , Tuberculosis, Gastrointestinal/drug therapyABSTRACT
Portal hypertensive colopathy (PHC) is a recently described entity in patients with portal hypertension which can cause even life-threatening lower gastrointestinal bleeding. In contrast to variceal bleed, there is no standardized treatment for the control of bleeding from these lesions. We report a case of alcoholic cirrhosis with portal hypertension, in whom bleeding from colonic angiodysplasia-like lesions was effectively controlled by somatostatin infusion.
Subject(s)
Acute Disease , Colonic Diseases/drug therapy , Gastrointestinal Hemorrhage/drug therapy , Humans , Hypertension, Portal/complications , Liver Cirrhosis, Alcoholic/complications , Male , Middle Aged , Somatostatin/therapeutic useABSTRACT
Se presenta una paciente de 42 años que consultó por dolor en hemiabdomen inferior, constipación y proctorragia durante los períodos menstruales. En el estudio baritado del colon se observó un defecto de relleno que ocupaba parcialmente la luz a la altura de la unión rectosigmoidea la alparoscospía confirmó la presunción clínica de endometriosis. Recibió tratamiento por 6 meses con danazol durante ese lapso presentó efectos adversos que remitieron con la suspensión de la droga. La paciente permaneció asintom tica tras dos años de seguimiento. Se discuten datos bibliogr ficos cocernientes al diagnóstico y a la terapéutica de esta entidad.
Subject(s)
Adult , Female , Humans , Colonic Diseases/drug therapy , Danazol/therapeutic use , Endometriosis/drug therapy , Estrogen Antagonists/therapeutic use , Colonic Diseases/diagnosis , Danazol/adverse effects , Endometriosis/diagnosis , Follow-Up StudiesABSTRACT
Tres peu de chirurgiens defendent la non-preparation du colon (ou du rectum). Cependant; a y regarder de plus pres; il apparait que les partisans de cette attitude prescrivent; tous; a un moment ou a un autre; a leur patient un regime et quelques sulfamides intestinaux. La plupart des auteurs ont utilise une preparation qu'on peut appeler classique et qui comporte un regime sans residus; des laxatifs et des lavements evacuateurs. [abstract terminated]
Subject(s)
Colonic Diseases/drug therapy , Colonic Diseases/surgery , Rectal Diseases/drug therapy , Rectal Diseases/surgeryABSTRACT
Cincuenta y nueve pacientes sometidos a cirugía colorrectal electiva recibieron preparación de colon por vía anterógrada y profilaxis antibiótica en dosis única con ceftriaxona y ornidazol. La preparación utilizada fue bien tolerada, obteniendo una adecuada limpieza del lumen intestinal y minimizando las alteraciones hidroelectrolíticas y del equilibrio ácido-base. No hubo sepsis ni complicaciones sépticas graves intraabdominales.
Subject(s)
Adolescent , Adult , Middle Aged , Humans , Male , Female , Ceftriaxone/therapeutic use , Colonic Diseases/drug therapy , Ornidazole/therapeutic use , Rectal Diseases/drug therapy , Colonic Diseases/surgery , Rectal Diseases/surgeryABSTRACT
La pirenzepina se ha utilizado ampliamente en el tratamiento de la úlcera gástrica y duodenal. En este trabajo hemos probado que esta droga puede prevenir la acción inflamatoria inducida en el colon con un estímulo intraluminal como el ácido acético. Estos datos sugieren una participación colinérgica en la respuesta inflamatoria del colon