ABSTRACT
A case-control study was carried out on patients of myocardial infarction selected from coronary care unit of Lok Nayak Jai Prakash Narayan Hospital, Delhi. The study was carried out to determine the association of haptoglobin (Hp), transferrin (Tf) and complement component 3 (C3) polymorphism with myocardial infarction. The frequency of allele Hp1 was found to be 0.159 in cases studied and 0.058 in controls. The frequency of gene TfC was found to be 0.987 in cases of study and 0.992 in controls. Similarly, frequency of CS3 gene was found to be 0.985 and 0.990 in cases studied and controls respectively. The comparison between cases studied and controls with respect to TfC and CS3 polymorphism was found to be statistically non-significant while the comparison between cases studied and controls for Hp polymorphism was found to be statistically significant (chi 2 = 21.88, p < 0.01).
Subject(s)
Case-Control Studies , Complement C3/genetics , Coronary Disease/genetics , Gene Frequency , Genetic Markers/genetics , Genetic Predisposition to Disease/genetics , Haptoglobins/genetics , Humans , India , Myocardial Infarction/genetics , Phenotype , Polymorphism, Genetic , Transferrin/geneticsABSTRACT
A variabilidade genética do fator B (BF) e do componente C3 do sistema complemento foi investigada numa populaçäo indígena Guarani do sul do Brasil. Foram analisados 70 indivíduos. As seguintes freqüências alélicas do loco BF foram observadas: BF*S=0,979, BF*F=0,014, BF*S05=0,007. A freqüência do alelo C3*S foi estimada em 100 por ciento. O alelo BF*S05 foi encontrado apenas em populaçöes sul-brasileiras, inclusive em índios Kaingang, o que indica que tenha se originado em indígenas sul-americanos. O baixo grau de polimorfismo de BF e o monomorfismo de C3, observado nos índios Guarani, estäo de acordo com os padröes de variabilidade observados em outras populaçöes ameríndias, esquimós e asiáticas.