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Braz. j. med. biol. res ; 22(1): 77-80, 1989. ilus, tab
Article in English | LILACS | ID: lil-67485

ABSTRACT

C3H mice infected intravenously with the JHM strain of coronavirus showed high incidence of demyelination (44.8%) and low incidence of encephalitis-induced mortality (6.9%). High titers of virus were detectable in the brain and liver of mice only during the first 3 to 12 days of infection (10 and 10 PFU/g, respectively). Most of the animals recovered from the first phase of disease and some (1.1%) came down with paralysis 6 to 7 weeks after the infection, with no histological changes or virus detectable in their tissues


Subject(s)
Mice , Animals , Coronaviridae/pathogenicity , Coronavirus Infections/complications , Demyelinating Diseases/etiology , Encephalomyelitis/etiology , Brain Stem/ultrastructure , Mice, Inbred C3H , Virus Activation
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