ABSTRACT
We report a 64 years-old woman who underwent sparing mastectomy with adjuvant radiotherapy for breast cancer. One month after the end of radiotherapy, she presented with malaise, fever, fatigue, cough and migratory bilateral pulmonary infiltrates on serial radiological images. The microbiological studies of broncha alveolar lavage were negative. The patient under went a trans bronchial biopsy and the pathological diagnosis was compatible with an organizing pneumonia presumably associated with radiotherapy. Systemic steroid treatment was successful with rapid and complete resolution ofclinical and radiographic manifestations.
Subject(s)
Female , Humans , Middle Aged , Cryptogenic Organizing Pneumonia/etiology , Radiation Pneumonitis/etiology , Breast Neoplasms/radiotherapy , Breast Neoplasms/surgery , Radiotherapy, Adjuvant/adverse effectsABSTRACT
A 60-year-old man presented with cough, sputum, and dyspnea. He had a history of acute myeloid leukemia and hematopoietic stem cell transplantation with chronic renal failure. Chest CT scans showed miliary nodules and patchy consolidations. Histological examination revealed numerous fibrin balls within the alveoli and thickening of the alveolar septum, both of which are typical pathological features of acute fibrinous and organizing pneumonia (AFOP). We report the first case of AFOP following allogeneic hematopoietic stem cell transplantation.
Subject(s)
Humans , Male , Middle Aged , Acute Disease , Anti-Bacterial Agents/therapeutic use , Biopsy , Cryptogenic Organizing Pneumonia/etiology , Fatal Outcome , Glucocorticoids/administration & dosage , Hematopoietic Stem Cell Transplantation/adverse effects , Hemoptysis/etiology , Leukemia, Myeloid, Acute/surgery , Lung Diseases/etiology , Pleural Effusion/etiology , Pulse Therapy, Drug , Radiography, Thoracic , Respiratory Insufficiency/etiology , Tomography, X-Ray ComputedABSTRACT
A 67-year-old diabetic man presented with progressive multifocal myeloradiculopathy for 6 months, with no pulmonary symptoms. A chest x-ray and CT scan of the lungs revealed bilateral multiple nodular infiltrates in the right upper lobe and the lower lobes bilaterally, mimicking metastases. A thoracoscopic lung biopsy demonstrated bronchiolitis obliterans organizing pneumonia caused by capsule-deficient cryptococcosis.
Subject(s)
Aged , Cryptococcosis/complications , Cryptogenic Organizing Pneumonia/etiology , Humans , MaleABSTRACT
A bronquiolite obliterante com pneumonia em organização (BOOP) é uma forma de comprometimento intersticial pulmonar da dermatopolimiosite. Na maioria dos casos, a BOOP ocorre simultaneamente ou após o diagnóstico da miosite, porém é rara como manifestação inicial. Os autores descrevem uma paciente com BOOP idiopática que após cinco anos desenvolve polimiosite clássica e fazem revisão de literatura
Subject(s)
Humans , Female , Adult , Cryptogenic Organizing Pneumonia/etiology , PolymyositisABSTRACT
The uncommon bronchiolitis obliterans organizing pneumonia can be idiopathic or caused by infection or medications. We report a 5 year old boy with pericardial sarcoma that was treated with chemotherapy (vincristine, doxorubicin, etoposide, cyclophosphamide) and radiotherapy. During the third cycle of chemotherapy, he developed progressive cough and dyspnea, needing oxygen therapy. Chest X-ray examination showed bilteral infiltrates. After discarding infectious etiologies, an open lung biopsy was performed, and the pathological examination showed a bronchiolitis obliterans organizing pneumonia. He was treated with prednisolone for 7 days, followed by prednisone for additional 45 days. He continued with fluticasone propionate as maintenance and remains in good condition with a ches X ray showing mild interstitial images, after seven months of follow up