Development of a nomogram for predicting survival of patients with ovarian serous cystadenocarcinoma after based on SEER database / 浙江大学学报·医学版

To develop a survival time prediction model for patients with ovarian serous cystadenocarcinoma after surgery. A retrospective analysis of 5906 postoperative patients with ovarian serous cystadenocarcinoma in the surveillance, epidemiology, and end results (SEER) database from 2010 to 2015 was performed. The independent risk factors for long-term survival were analyzed with multivariate Cox proportional hazard regression model. The nomogram of 3-year and 5-year survival was developed by using R language. The receiver operator characteristic (ROC) curve and were used to test the discrimination of the model and the calibration diagram was used to evaluate the degree of calibration of the prediction model. The survival curves was conducted by the risk factors. Cox proportional hazard regression model showed that age, race, histological grade (poorly differentiated and undifferentiated), stage T (T2a, T2b, T2c, T3a, T3b and T3c), and stage M (M1) were independent factors for the prognosis of patients with ovarian serous cystadenocarcinoma after surgery. A nomogram was developed by the R language tool for predicting the 3-year and survival of patients through age, race, histological classification, stage T and stage M. The C-index was 0.688 and the areas under ROC curve of the nomogram for predicting 3-year and 5-year survival were 0.708 and 0.716, respectively. The results of the calibration indicated that the predicted values were consistent with the actual values in the prediction models. The survival time of patients with high-risk factors was shorter than that of patients with low-risk factors (<0.05). The developed nomogram in this study can be used to predict 3-year and 5-year survival of postoperative patients with ovarian serous cystadenocarcinoma, and it may be beneficial to guide clinical treatment.

Regresión biológica espontánea de gliomas de las vías ópticas: un prototipo de tumores de San Peregrino / Spontaneous biological regression of the visual pathway gliomas: a Saint Pellegrino prototype tumors

San Peregrino Lanziosi es considerado el patrón de los pacientes con cáncer y por extensión, de aquellos con HIV/SIDA. Un episodio revelador tuvo lugar hacia 1325, cuando contaba cerca de sesenta años. Una gangrena dolorosa en su pierna derecha se tornó tan seria que su médico le propuso la amputación. En la noche previa a la cirugía, con gran dificultad Peregrino se arrastró hasta un Cristo crucificado localizado en una pared del cuarto y allí, suplicó a Jesús que le curara. Mientras se encontraba medio dormido vio al Señor tocar su pierna mortificada la cual fue curada instantáneamente y en forma espontánea. Desde la ocurrencia del milagro, aquellos tumores que regresan biológicamente hasta desaparecer, son llamados tumores de San Peregrino. Los gliomas de las vías visuales son tumores multifacéticos. Considerados como gliomas pilocíticos benignos juveniles, en algunos casos pueden mostrar progresión invadiendo estructuras de cercanía y causando pérdida visual. En otros permanecen estables por muchos años, y en una cantidad no determinada, aún exhiben regresión biológica espontánea con mejoría de los síntomas. El fenómeno de la regresión espontánea de tumores benignos y malignos está bien documentada en la literatura y comúnmente se atribuye a la inducción de apoptosis o la activación del sistema inmune. Es de crucial importancia el que este fenómeno sea tomado en consideración siempre que se evalúen los resultados de algún tratamiento (resección quirúrgica, radiación o quimioterapia). Apoyado en una secuencia de neuroimágenes, el autor comunica tres de tales casos, ninguno de ellos era portador de una neurofibromatosis tipo 1 (NF-1)

Saint Pellegrino Lanziosi is considered the patron of patients with cancer, and by extension of those with HIV infection/AIDS. A revealing episode took place around 1325, when he was almost sixty years old. A painful gangrene in his right leg became so serious that the friary physician had to amputate the sore limb. The night before the operation Pellegrino crawled with great difficulty to the large Crucifix located inside his room and there he besought Jesus to heal him. While he was half-asleep, he saw Jesus touching his sore leg and he was instantly and spontaneously healed. Since the occurrence of this miracle, tumors that biologically recede until they disappear are known as Saint Pellegrino tumors. Visual pathway gliomas are multifaceted tumors. Although they are considered as benign juvenile pilocytic gliomas, in some cases they may progress, invading neighboring structures and causing loss of vision. In other cases, they remain stable for years, and may even shrink, showing spontaneous biological regression with improvement of related symptoms. The phenomenon of spontaneous regression of benign and malignant tumors is well documented in the literature and is commonly attributed to the induction of apoptosis or the activation of the immune system. It is crucially important that this phenomenon be taken into consideration whenever the results of therapy (surgical resection, radiation, and chemotherapy) are being evaluated. Supported by a sequence of neuroimages, the author communicates three of these cases. None of them were carriers of neurofibromatosis type 1 (NF-1)

Degeneraçao cerebelar subaguda paraneoplásica: relato de caso / Paraneoplastic subacute cerebellar degeneration: case report

Descrevemos caso de uma paciente de 40 anos com quadro de degeneraçao cerebelar subaguda paraneoplásica associada a tumor ovariano. Apresentamos breve revisao sobre as manifestaçoes clínicas e laboratoriais desta síndrome, enfatizando a importância do seu reconhecimento, o que possibilita muitas vezes a detecçao e tratamento precoce da doença primária

Cistoadenoma seroso microquisto del pancreas aspectos clinicopatologicos y quirurgicos / Microcystic serous cystadenoma of pancreas. Clinicopathological and surgical features

The microcystic serous cystadenoma of pancreas or glycogen "rich"cystadenoma is a rare entity. Whe studiet five case of this cystadenoma in adult patients ages 47-68 (58 was the mean), four of wich were women (80 percent). The clinical presentation was varied. There was a prevalence of expansive manifestations with epigastric pain in three patients, and extrahepatic bile duct obstruction in other two. A distal tumour was revealed by the diagnostic methodology used (ultrasound and TAC) in three patients, and cephalic tumour in two, with a mean size of 8.8 cm. in diameter. A distal pancreatectomy was performed in two patients, a cephalic pancreatoduodenectomy was performed in one in relation with the presence of extrahepatic bile duct carcinoma, and the other two were treated with a partial cephalic pancreatectomy (enucleation). The nosological diagnose was post-surgical in all case of study. a prognosis for every case was dependat of the associated pathology.