ABSTRACT
The antifungal activity of the ethanol and boiled water crude extracts of Acalypha wilkesiana leaves were investigated. Extracts were obtained from the leaves collected every 3 hrs within a 24 hrs rhythm or setting. All the crude extract had significant antifungal activity on all the fungi tested [Aspergillus flavus, Aspergillus fumigatus, Aspergillus niger, Candida albicans, Microsporum audonii, Penicillium chrysogenum, Rhizopus sp., Trichoderma viride, and Trichophyton mentagrophyte]. There was a definite change in the antifungal activity of crude extracts of A. wilkesiana leaves harvested at different times of the day [3 am, 6 am, 9 am, 12 noon, 3 pm, 6 pm, 9 pm, 12 midnight]. The crude extracts of leaves harvested at 3 am had the highest zone of inhibition while the least inhibition was at 12 noon. The boiled water extract was more active as antifungal than the ethanol extract. The efficacy of the antifungal properties of the leaves harvested at 3 am is probably as good as the check antibiotics Fulcin and Nystatin. Preliminary phytochemical studies of the crude extracts reveal that the ethanol extracts contain cardiac-glycosides, saponins, steroid, and tannins. The boiled extract contains alkaloids, flavonoids cardiac-glycosides, phlobatannins, saponins, steroids and tannins. In this paper significance of the result is discussed
Subject(s)
Euphorbiaceae , Dermatomycoses/therapy , Dermatomycoses/prevention & control , Plants, Medicinal , Plant Extracts , Plant LeavesABSTRACT
Seventy cattle suspected to dermatophytosis were examined between March and April 2003. The samples were taken from different lesions by scraping method. Direct microscopic examination and culture were carried out. The mean of infection duration was 2 weeks. Forty-three cases were appeared with positive clinical signs of dermatophytosis and 27 cases were asymptomatic. The etiologic agent of the infection was only Trichophyton verrucosum. A significant relation was observed between the frequency of head and neck lesions and other sites. There was a significant difference between the frequency of head lesions and other sites. Since human dermatophyte infections due to Trichophyton verrucosum have been reported repeatedly in Iran, it is necessary to design a preventive program such as developing an effective vaccine against dermatophytosis into the future
Subject(s)
Animals , Dermatomycoses/epidemiology , Dermatomycoses/prevention & control , Microscopy , Trichophyton/pathogenicity , Cattle Diseases , CattleABSTRACT
A tinea pedis é uma das micoses mais freqüentes, ocorrendo em diversas classes de pacientes. Para tratamento desta micose, têm sido utilizados antimicóticos específicos de uso tópico ou sistêmico. No entanto, o amplo uso principalmente das drogas sistêmicas tem mostrado que podem ser tóxicas para o hospedeiro e muitas vezes ineficazes. Por isso, tem sido crescente o interesse de se utilizar substâncias de atividade inespecífica para tratamento de micoses superficiais. O objetivo deste trabalho foi selecionar paciente com suspeita de dermatomicose podal, isolar e identificar os fungos causadores da micose. Em adiçäo, realizar o tratamento tópico, avaliaçäo terapêutica e antibiograma dos dermatófitos isolados com antifúngicos comercialmente disponíveis...
Subject(s)
Humans , Antifungal Agents/therapeutic use , Dermatomycoses/prevention & control , Microbial Sensitivity Tests , Tinea , Arthrodermataceae/isolation & purification , Culture Media , Trichophyton/isolation & purificationABSTRACT
Estudio multicéntrico realizado con la participación de médicos de diferentes áreas de todo el país para evaluar la utilidad del empleo del Itraconazol, por vía oral, para el tratamiento de la dermatomicosis. La población estuvo constituida por 375 pacientes, 202 hombres y 173 mujeres. Los promedios de edad, peso y talla fueron 34.2 años, 64.3 kg Y 165.5 cm respectivamente. Todos los pacientes tenían diagnóstico clínico de dermatomicosis comprobada por KOH, cultivo y prueba de lámpara de Wood. Cada paciente recibió 100 mgr diarios de Itraconazol, vía oral, durante 15 días. Se efectuaron controles clínicos a la semana, durante dos semanas y al mes de haber Iniciado el tratamiento. El 62.1 por ciento de los pacientes presenta curación clínica y micológica, el 84.1 por ciento presentó curación micológica. La mejor respuesta se observó en la candidiasis cutánea, la tiña corporis, la tiña corporis, la pitiriasis y la candidiasis Interdigital...
Subject(s)
Dermatomycoses , Dermatomycoses/prevention & control , ItraconazoleABSTRACT
Se demuestra la eficacia de los vapores de formaldehído en escamas de piel de lesiones de micosis superficiales, siendo cultivadas durante 72 horas y comparadas con cultivos controles positivos. En el 95% de las muestras no hubo crecimiento micótico independiente del tiempo de exposición. Los autores sugieren que el uso de vapores de formalgehído es un método eficaz para la esterilización de fomites en aquellos pacientes con micosis superficiales