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Indian J Hum Genet ; 2013 July-Sept ;19 (3): 342-345
Article in English | IMSEAR | ID: sea-156588

ABSTRACT

OBJECTIVES: The objective of this study is to determine the inheritance pattern of type‑2 diabetes and make stratification for the general population risk. MATERIALS AND METHODS: A questionnaire was developed for o btaining the family history. Analysis of the data was carried out by using student and Chi‑square tests and for stratification; the guidelines of Scheuner et al. were followed. RESULTS: The pattern of inheritance is the male sex specific (χ² =13.44). The mean age of onset of diabetes in parents was 58.61 ± 2.94 and in offspring 46.75 ± 2.54. In all 47.22 ± 11.53% families were found in high risk and 31.94 ± 10.77% in the moderate risk category. In female diabetics, the onset was in the age range of 41‑60 years. CONCLUSION: We found a high‑risk of diabetes and familial clustering in successive generations of Brahmins with prominent male sex specificity. In females onset of diabetes was coinciding with the period around menopause.


Subject(s)
Adult , Diabetes Mellitus, Type 2/analysis , Diabetes Mellitus, Type 2/epidemiology , Diabetes Mellitus, Type 2/genetics , Family/history , Female , Humans , India/epidemiology , Inheritance Patterns/genetics , Prevalence , Population Groups/genetics , Population Groups/history , Risk Assessment
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