Patterns of lipid changes among type 2 diabetes patients in Sudan

This study investigated the patterns and determinants of lipid disorders among a group of 250 type 2 adult diabetic patients and 60 age- and sex-matched healthy controls in Sudan. Demographic and clinical data, body mass index and waist circumference, and fasting blood samples were taken to estimate the glucose and lipid profile. The mean duration of diabetes was 9.4 years and 46.0% of patients had poor glycaemic control. Compared to controls we detected a statistically significant increase in triglycerides level and a decrease in HDL-C levels. Other lipid values showed a slight increase compared to controls. There was a statistically significant association of triglycerides and HDL-C with increasing age, female sex, obesity, physical inactivity and poor glycaemic control of diabetes

Comparison of patterns of lipid profile in type-2 diabetics and non-diabetics

To determine the commonest pattern of lipid profile in type 2 diabetics presenting in Mayo hospital and to compare it with non-diabetics. It was a comparative study. It was conducted in all medical wards, medical OPD and patients seen in emergency. Material and method: Patients were selected according to inclusion criteria. After sampling for all relevant investigations, results were expressed after applying Chi-square test. Serum cholesterol> 240mg/dl seen in 25% diabetics and 11% non-diabetics [p <0.05]. Levels <240 and >200mg/dl seen in 35% diabetics and 19% non-diabetics [p <0.05]. Serum cholesterol < 200mg/dl seen in 40% diabetics and 70% non-diabetics [p<0.05].LDL >160mg/dl seen in 21% diabetics and 5% non-diabetics [p<0.01]. LDL < 130 mg/dl seen in 32% diabetics and 42% non-diabetics [p >0.05].HDL < 35 mg/dl seen in 67% diabetics and 43% non-diabetics [p <0.05]. HDL >35mg/ dl seen in 33% diabetics and 57% non-diabetics [p <0.05]. TG >400 mg/dl seen in 8% diabetics and 3% non-diabetics.TG >200mg/dl seen in 38% diabetics and 93% non-diabetics [p<0.01].TG <200mg/dl seen in 62% diabetics and 3% non-diabetics [p<0.01]. Diabetes and cardiovascular disease are closely associated. Diabetic dyslipidaemias are a major risk factor for athrosclerosis. The commonest dyslipidaemia found was low HDL cholesterol followed by high LDL, serum cholesterol and TG levels.The commonest dylipidaemia found among non-diabetics in this study is high TG and low HDL,which might be associated with dietary factors and lack of exercise. Correction of dyslipidaemia is important to retard the progression of atherosclerosis