ABSTRACT
Abstract: Dermatitis herpetiformis and linear IgA bullous dermatosis are autoimmune diseases that present with pruritic urticarial papules and plaques, with formation of vesicles and blisters of subepidermal location, mediated by IgA antibodies. Mucosal lesions are present only in linear IgA bullous dermatosis. The elaboration of this consensus consisted of a brief presentation of the different aspects of these dermatoses and, above all, of an updated literature review on the various therapeutic options that were discussed and compared with the authors' experience, aiming at the treatment orientation of these diseases in Brazil. Dermatitis herpetiformis is a cutaneous manifestation of celiac disease, and can be controlled with a gluten-free diet and dapsone. On the other hand, linear IgA bullous dermatosis arises spontaneously or is triggered by drugs, and can be controlled with dapsone, but often requires the association of systemic corticosteroids and eventually immunosuppressants.
Subject(s)
Humans , Consensus , Linear IgA Bullous Dermatosis/drug therapy , Prognosis , Societies, Medical , Brazil , Dermatitis Herpetiformis/therapy , Adrenal Cortex Hormones/therapeutic use , Dapsone/therapeutic use , Dermatology , Diet, Gluten-Free/methods , Anti-Inflammatory AgentsABSTRACT
Remission of gastrointestinal and general symptoms after gluten withdrawal has been described in some non-celiac individuals for nearly 30 years. Only recently, efforts have been made to define this entity, now referred to as "non- celiac gluten sensitivity". It includes patients that clinically respond to gluten free diet without exhibiting allergic or autoimmune features to explain such response. Wheat allergy, celiac disease, irritable bowel syndrome and symptoms induced by high FODMAPs (Fermentable, Oligo-, Di-, Mono-saccharides And Polyols) consumption are the main differential diagnoses. The relationship with neuropsychiatric disorders such as schizophrenia and autism has not been demonstrated, but currently it gives ground to great hope in families with affected children. Epidemiology of non-celiac gluten sensitivity is not clear. It is described as more common among women and less common in children. Genetic and immune factors, changes in intestinal microbiota and non-gluten components present in wheat grains are main factors postulated in the pathogenesis of this condition. To date, there are no specific biomarkers for non-celiac gluten sensitivity and diagnosis is reached by excluding other causes of disease. A trial with gluten-free diet and subsequent gluten challenge is the methodology most frequently used to confirm diagnosis.
Subject(s)
Humans , Food Hypersensitivity/diagnosis , Glutens/adverse effects , Autistic Disorder/etiology , Autistic Disorder/psychology , Celiac Disease/diagnosis , Celiac Disease/physiopathology , Diagnosis, Differential , Diet, Gluten-Free/methods , Food Hypersensitivity/complications , Food Hypersensitivity/diet therapy , Food Hypersensitivity/physiopathology , Irritable Bowel Syndrome/diagnosis , Irritable Bowel Syndrome/physiopathology , Schizophrenia , Wheat Hypersensitivity/complicationsABSTRACT
Gluten sensitivity is one of the prominent features of celiac disease (CD) which is an autoimmune disorder characterized by damaged lining of the small intestine. CD was known already to ancient Greeks as κοιλιακός (keeleeakoss) i.e. disease of the abdominal cavity hence celiac. Focus of this Commentary article is on rather complex definition of CD and its emerging new forms the example of which is non-celiac gluten sensitivity. It is becoming evident that to formulate more effective treatments, these associations and newly identified disease entities deserve attention from both academic and clinical communities.
Subject(s)
Autoimmune Diseases/therapy , Autoimmunity , Celiac Disease/classification , Celiac Disease/therapy , Diet, Gluten-Free/methods , Glutens , Humans , TransglutaminasesABSTRACT
the association of diabetes type 1 and celiac disease seems to pose many problems diagnostic, therapeutic and psychological. Aim of our work is to study in eight patients with type 1 diabetes associated with celiac disease their daily experience and the constraints that this pathological association imposes. This cross-sectional study involved eight patients with type 1 diabetes and celiac disease known for at least 1 year. All patients were given a thorough interrogation specifying the regular monitoring of the two diseases and the quality of the observance of the diabetic dietary and gluten-free diet, as well as an assessment of impact of diabetes. the caloric intake in relation to the recommendations is very insufficient. Taking snack is not respected. There is also the consumption of certain foods containing gluten masked and regular consumption of sucrose by our patients despite a long-term evolution of diabetes [19 +/- 6 years] and celiac disease [11 +/- 7.8 years]. Half of patients have degenerative complications of diabetes. In light of these results, a frequent evaluation of nutrition education in these patients and a psychological care seems necessary