ABSTRACT
It is estimated that more than 1 billion people worldwide have vitamin D insufficiency or deficiency. Vitamin D participates in bone mineralization, and is therefore important in osteoporosis, osteomalacia and rickets prevention. However, vitamin D deficiency could also be associated with several other pathologies. The present study aimed to investigate the relationships between vitamin D deficiency and vitamin D deficiency-related disorders in patients. In addition, this study aims to verify if countries with low solar incidence have higher extraskeletal disease death rates when compared to countries with high solar incidence. The vitamin D concentrations were obtained from the Heart Hospital database (Natal/Brazil). The relationship between solar incidenceand death rate for vitamin D deficiency-related disorders was verified. Death rate data were extracted from the 'World Life Expectancy' repository and data about solar incidence were obtained from NASA's Surface Meteorology and Solar Energy project. Thesedata were statistically processed with IBM SPSS v23.0 software and R programming language. Our results showed that patients with vitamin D insufficiency/deficiency showed significantly more bone diseases, thyroid diseases, hypercholesterolemy, hypertriglyceridemia, cancers, diabetes, hepatobiliary diseases, and urinary system diseases. Moreover, countries with high solar incidence have low cancer and multiple sclerosis death rates. This work suggests the participation of vitamin D and sunlight incidence inseveral diseases.
Subject(s)
Male , Female , Adolescent , Adult , Middle Aged , Aged , Sunlight , Vitamin D Deficiency/mortality , Bone Diseases/mortality , Thyroid Gland/abnormalities , Urologic Diseases , Hypertriglyceridemia/complications , Life Expectancy/trends , Diabetes Mellitus , Digestive System Diseases/complications , Hypercholesterolemia/complications , NeoplasmsABSTRACT
The present review addresses liver and gastrointestinal diseases that are more frequently associated to osteopenia and osteoporosis. For each disease, we describe the prevalence and physiopathology of these bone metabolism conditions. The purpose is to create awareness of this scenario and prompt early analysis if these patients, and in other cases, to provide prophylaxis and treatment of these disorders.
En esta revisión se abordan las enfermedades hepáticas y del tubo digestivo que con mayor frecuencia se asocian a osteopenia y osteoporosis. En cada patología describimos la prevalencia y fisiopatología de estas afecciones del metabolismo óseo. El objetivo es dar a conocer esta realidad e inducir a que estos pacientes sean estudiados precozmente, en otros casos aplicar la profilaxis y tratar estos desórdenes.
Subject(s)
Humans , Bone Diseases, Metabolic/complications , Bone Diseases, Metabolic/epidemiology , Digestive System Diseases/complications , Digestive System Diseases/epidemiology , Osteoporosis , Bone Diseases, Metabolic/physiopathology , Bone Diseases, Metabolic/chemically induced , Digestive System Diseases/physiopathology , Proton Pump Inhibitors/adverse effects , Liver DiseasesABSTRACT
Numerosas enfermedades sistémicas y metabólicas tienen manifestaciones cutáneas, muchas de estas manifestaciones pueden favorecer su diagnóstico. Dado el gran número de estas patologías, esta revisión no pretende ser un análisis exhaustivo de todas ellas, sino que presenta un análisis clínico-patológico de algunas enfermedades metabólicas y sistémicas seleccionadas.
Numerous systemic and metabolic diseases have coetaneous manifestations, many of these manifestations can favor diagnosis Due to the great number of these conditions, this review does not try to be a comprehensive analysis of all of them, but present a clinicopathological analysis of some selected metabolic and systemic diseases.
Subject(s)
Humans , Metabolic Diseases/complications , Skin Diseases/etiology , Digestive System Diseases/complications , Nervous System Diseases/complications , Acrodermatitis/complications , CADASIL , Diabetes Complications , Hartnup Disease/complications , Lafora Disease/complications , Tangier Disease/complications , Whipple Disease/complications , Skin Diseases, Metabolic/etiology , Inflammatory Bowel Diseases/complications , Glucagonoma/complications , Porphyrias/complicationsABSTRACT
Estudou-se uma populaçäo de 46 pacientes reumáticos com relaçäo às queixas digestivas. Observou-se uma grande incidência de queixas digestivas, independentes do tipo de droga utilizada. Näo foram observados alteraçöes significativas com relaçäo ao tabagismo, uso profilático de leite e incidência de queixas. Os pacientes do sexo feminino apresentaram significativamente mais queixas do que os pacientes do sexo masculino