ABSTRACT
Some studies on human beings have suggested that during normal pregnancies an increase in the number of Th2 cells and in women with recurrent spontaneous abortions [RSA] an increase in Th1 cells takes place. The Cross-link of CD26 and CD3 on T-cells with immobilized monoclonal antibodies results in T-cell proliferation and IL-2 [Th1 cytokine] production. CD30 has been described as being preferentially expressed, and sCD30 preferentially released by human T-cells that produce Th2-type cytokines. The objective of this study was to determine whether serum levels of soluble CD26 [sCD26] and CD30 [sCD30] as markers of Th1 and Th2, alter in patients with a history of recurrent spontaneous abortion [RSA], and whether there is any correlation between cytokine production by stimulated peripheral blood mononuclear cells [PBMCs] and serum levels of soluble CD26 and CD30. This was a case-control study on two different groups of people referred to Yazd Research and Clinical Center for Infertility. The case group consisted of 21 women with at least 3 abortions. The participants were visited on the day of their last abortion. The control group consisted of 32 pregnant women without any abortions and with a history of at least one successfully terminated pregnancy. The serum levels of sCD26 and sCD30 and levels of IL-2, IL-4, IL-10, IL-13 and IFN