ABSTRACT
In atherogenic diet induced hyperlipidemic model, the rats receiving treatment with the aqueous extract of the leaves of E. prostrata showed significant reduction in total cholesterol, triglyceride, total protein and elevation in high density lipoprotein cholesterol.The aqueous extract of E. prostrata was found to possess significant hypolipidemic activity. The results also suggest that E. prostrata leaf extract at 100 and 200 mg/kg b.wt. concentrations is an excellent lipid-lowering agent.
Subject(s)
Animals , Hypolipidemic Agents/chemistry , Atherosclerosis , Diet, Atherogenic , Eclipta/metabolism , Hyperlipidemias/metabolism , Lipids/blood , Male , Plant Extracts/chemistry , Plant Leaves/metabolism , Plants, Medicinal/metabolism , Rats , Rats, Wistar , Triglycerides/metabolism , Water/metabolismABSTRACT
Influence of different environmental factors on accumulation of wedelolactone, a potential anti-hepatotoxic principle of E. alba in shoot cultures was investigated. A significant increase in the content of wedelolactone due to kinetin treatment, temperature change and photoperiod alteration in shoot cultures was observed. Incorporation of phenylalanine in the medium also increased content of wedelolactone significantly in a dose-dependent manner.