Liver involvement in endocrine diseases / 中华肝脏病杂志

As a secondary endocrine organ, the liver is closely related to the endocrine system. Liver involvement is not uncommon in endocrine diseases, such as hyper/hypothyroidism, diabetes, dysfunction of adrenal and gonadal. It can be manifested in a variety of forms, including hepatocyte injury (elevated transaminase), bile duct injury (cholestasis), hepatocyte steatosis, vascular injury and liver tumor. Direct and indirect liver injury caused by abnormal hormone levels and side effects of drugs for the treatment of endocrine diseases are common pathogenesis. In addition, endocrine diseases can be concomitant with liver diseases, such as autoimmune thyroiditis and autoimmune hepatitis. Systemic diseases can also involve the endocrine system and liver at the same time, such as systemic lupus erythematosus and IgG4 related diseases. For patients with unexplained liver injury, endocrine system diseases should be considered as the differential diagnosis.

Transtorno del crecimiento en el niño y adolescente con diabetes mellitus tipo I

Los efectos de la diabetes mellitus tipo 1 sobre el crecimiento y desarrollo de niños y adolescentes son aún controversiales. Algunos grupos de investigadores afirman que la diabetes en la edad pediátrica va a alterar el crecimiento de los niños, independiente del grupo de control metabólico y otros, incluyendo nuestro grupo, hemos demostrado que el paciente con un llamado "mal control" metabólico con hiperglicemia crónica reflejadas por niveles de hemoglobina glicosilada (HbA1C) elevados, van a presentar una disminución de la velocidad de crecimiento y por tanto terminan con una talla final más baja que su potencial genético. El objetivo de este trabajo es realizar un análisis del efecto que tiene la diabetes sobre la fisiopatología de los factores de crecimiento y como repercuten los mismos sobre las anormalidades que se presentan en la clínica y la auxología del niño y adolescente con diabetes mellitus tipo 1

The effect of type 1 diabetes mellitus on the growth and development of children and adolescents remains controversial. Some groups of investigators have reported that diabetes during the pediatric age will alter the growth of children, independently of the degree of metabolic control, while others, including our group, have demonstrated, that what is called a “poor metabolic bolic”control, with chronic hyperglycemia reflected by elevated HbA1C, will produce a decrease in growth velocity that will end in subjects with short stature for their genetic potential. The aim of this study is to analyze the effect that diabetes has on the physiopathology of growth factors and the role they play on the clinical and auxiological abnormalities that are seen in children with type 1 diabetes mellitus

Receptores acoplados à proteina G: implicaçöes para a fisiologia e doenças endócrinas / Connect receptors to G protein: implications for the physiology and endocrine diseases

A maioria dos hormônios polipeptídicos e mesmo o cálcio extracelular atuam em suas células-alvo através de receptores acoplados á proteína G (GPCRs). Nos últimos anos, tem sido frequente a identificação e associação causal de mutações em proteínas G e em GPCRs com diversas endocrinopatias, como diabetes insipidus nefrogênico, hipotiroidismo familiar, puberdade precoce familiar no sexo masculino e nódulos tiroidianos hiperfuncionantes. Nesta revisão, abordamos aspectos referentes ao mecanismo de transdução do sinal acoplado à proteína G, e descrevemos como mutações em GPCRs podem levar a algumas doenças endócrinas. Finalmente, comentamos a respeito das implicações diagnósticas e terapêuticas associadas com o maior conhecimento dos GPCRs.

Manifestaciones a nivel de cavidad oral de los trastornos endócrinos / Oral cavity manifestations of endocrine disorders

Se pretende con esta somera revisión resaltar los principales síntomas y signos que se presentan en la cavidad oral en el paciente afecto de una endocrinopatía particular