ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of acupuncture along affected meridian on the mem- brane metallo-endopeptidase (MME) gene expression of migraine patients without aura (MO) of Gan-yang hyperactivity syndrome (GYHS).</p><p><b>METHODS</b>Totally 20 MO patients of GYHS were randomly assigned to the acupoint group (acupuncture along affected meridian) and the non-acupoint group, 10 cases in each group. Needling was performed once per day for 10 consecutive days. Gene chip technology was used to obtain two sets of gene expression profiles and analyzed using Gene Ontology (GO).</p><p><b>RESULTS</b>In the acupoint group, MME gene expression decreased after needling (P = 0.0023).That gene was rich in the beta-amyloid metabolic process (P = 3.16E-05) and the peptide metabolic process (P = 0.009612). Its expression was not seen in the non-acupoint group.</p><p><b>CONCLUSION</b>The effect of point selection along affected meridian could be achieved possibly by regulating the MME gene expression.</p>
Subject(s)
Humans , Acupuncture , Acupuncture Points , Acupuncture Therapy , Endrin , Metabolism , Meridians , Migraine Disorders , Therapeutics , SyndromeABSTRACT
Subject(s)
Endrin , Hyalin , Myoepithelioma , Parotid Gland , S100 Proteins , Salivary Glands , VimentinSubject(s)
Pesticides/toxicity , Pesticides/poisoning , /toxicity , Endrin/toxicity , Mirex/toxicity , Lead/toxicity , /toxicity , /toxicityABSTRACT
Se presenta el caso de una paciente femenina de un año tres meses de edad quien en forma accidental ingirió "Endrín helios" (insecticida organoclorado ciclodieno) sobreviviendo a este evento. Clínicamente presentó crisis convulsivas sin aparentes secuelas neurológicas o hepáticas. Se realiza una revisión de los mecanismo de intoxicación por este tóxico, así como de la literatura al respecto. Itoxicaciones; crisis convulsivas; endrín, raticidas,; insecticidas
Subject(s)
Infant , Humans , Female , Poisoning , Endrin/adverse effects , Insecticides, Organochlorine/adverse effects , Mexico , Seizures/etiology , Seizures/therapyABSTRACT
The residue levels of Endrin were estimated in cucumber [Cucumis sativus] samples showed that 35.5% contained endrin residues ranging from 304.3 to 669.4 ug per 100 g vegetable. The calculated daily consumption of endrin by human population, thus falls between 13.1 and 28.7 ug per kg body weight. The disappearance of endrin in cucumber was also noted after spraying the insecticide in an experimental field. The residues persisted upto 14 days. Female albino rats receiving 28.7-ug endrin per kg body weight, accumulated endrin in their livers [5.47 ug/g] and its amount in the blood increased progressively [15.21 ug/ml] upto 28 days. The enzymes AST and ALT increased progressively, but no endrin was excreted in the faeces. The growth rate of rats as well as principal body organs, were adversely affected by the oral administration of the insecticide
Subject(s)
Endrin , Vegetables/analysis , RatsABSTRACT
La intoxicacion por el raticida endrin en 33 pacientes pediatricos se caracterizo por crisis convulsivas de inicio brusco, sin aura o fenomenos sensoriales, que evolucionaron rapidamente al estado epileptico. El laboratorio no aporto datos de interes y el electroencefalograma en 15 pacientes informo activacion centroencefalica paroxistica importante sin asimetrias ni focalizaciones. En dos ninos que murieron la autopsia mostro edema y congestion cerebral con degeneracion neuronal extensa La exposicion al endrin esta propiciada por su venta libre y uso sin control en el hogar lo que definitivamente debe prohibirse dada su peligrosidad y por no existir tratamiento especifico para la intoxicacion