ABSTRACT
There are many different treatment modalities for nocturnal enuresis. Options of treatment include behavior modifications and pharmacotherapy. The latter includes a scope of drugs like 1-deamine - 8 - D arginine vasopressin [D D A V P], tricyclic antidepressants. anticholinergics and other drugs. Aim of work is to study the efficacy of sympathomimetics [e.q ephedrine] in the treatment of nocturnal enuresis. Two hundred patients selected after complete history, examination, laborator, radiological and urodynamic study, those patients were given ephedrine HCL according to their age for 2 months and followed for 6 months. Complete dry bed: 172 patients [86%] within the first 2 weeks of treatment and the number increased to reach 189 patients [92%] after 2 months of treatment. Eight patients [4%] complained of relapse after 3 months of stoppage of treatment and the number increased after 6 months of stoppage of treatment to 13 patients [6.5%]. Alpha sympathomimetics [ephedrine HCL] is a cheap, simple, easy, effective and safe method for nocturnal enuresis treatment