Kimora disease [angiolymphoid hyperplasia with eosinophilia]

Kimora disease is one of the rarely encountered skin disorders which was first described by kimora in [1969] as a nodular angiolymphoid hyperplasia with eosinophilia. Wills and Whimster [1969] reoprted few cases of angiolymphoid hyperplasia with eosinophilia as the same disease. It was suggested by Lie et al, and accepted by Wilson Jones that kimora disease and temporal arteritis are the same disease. Wilson Jones and Bleehan presented many cases of small angiomatous nodules, showing proliferated blood vessels and numerous eosinophils, designated as Pseudogenic granulomas, which were considered to belong to Kimora Recently Mui PK et al [1989] denied the identity of angiolymphoid hyperplasia with eosinophilia and reported the name of Kimora lymphadcnopathy which considered as a disease with good prognosis. All the reported cases were from Japan and Europe and no specific drug was used for it. This is the first report from Arab countries [Fig.4] which was improved by using methotrexate with predinsoplone

Comparative distribution of eosinophils in bone marrow, blood and peritoneal cavity in murine schistosomiasis

Eosinophilia in murine schistosomiasis is very intense and extensive, involving distinct compartments such as bone marrow, blood, peritoneal cavity and tissues. Comparison of the shapes of eosinophil concentration or distribution curves showed a synchronization of the tendencies around 50% between blood and bone marrow, 33 to 64% between bloode and peritoneal cavity, and 33 to 43% between peritoneal cavity and bone marrow. The hepatic eosinophil granulocytopoiesis or metaplasia follows the same pattern as observed in bone marrow. Schistosoma infection can be divided into three distinct phases based on the eosinophilic response: 1) non- or low-productive phase (before 35-40 days of infection), 2) acute productive phase (from 35-40 to 70-90 days), and 3) chronic productive phase (after 70-90 days of infection)