ABSTRACT
Epidermodysplasia verruciformis (EV) is a rare, life-long heritable disease caused due to a unique susceptibility to human papilloma virus. The disseminated verrucous lesions and pityriasis versicolor-like lesions persist from early childhood and can transform into a cutaneous malignancy in a fourth of patients. Malignant transformation into syringoid eccrine carcinoma (SEC) has been reported only once so far. SEC is an extremely invasive, rare, locally destructive, slowly growing adnexal tumor. We hereby report the association of EV with SEC in a 29-year-old male.
Subject(s)
Adult , Carcinoma, Skin Appendage/complications , Carcinoma, Skin Appendage/pathology , Cell Transformation, Neoplastic , Epidermodysplasia Verruciformis/complications , Epidermodysplasia Verruciformis/pathology , Humans , Male , Papillomaviridae , Sweat Gland Neoplasms/complications , Sweat Gland Neoplasms/pathologyABSTRACT
We described 3 male patients with epidermodysplasia verruciformis seen in the Department of Dermatology and Venereology, Baghdad Teaching Hospital; their ages were 25, 30 and 34 years subsequently. They developed frequent multiple basal and squamous cell carcinoma, all of them had periorbital squamous cell carcinoma that invaded the orbit and ended with enucleation of their eyes. All available therapeutic measures failed to inhibit the progressiveness of these tumors. Great awareness and early management must be performed regarding any periorbital lesion in epidermodysplasia verruciformis patients
Subject(s)
Humans , Male , Carcinoma, Squamous Cell/complications , Epidermodysplasia Verruciformis/complications , Carcinoma, Squamous Cell/surgery , Carcinoma, Basal Cell/complications , Eye EnucleationABSTRACT
Descriçäo de um caso de epidermodisplasia verruciforme com acometimento ocular. A tumoraçäo corneana existente foi ressecada. Näo houve recidivas mesmo três anos após a intervençäo. Estudo histopatológico é apresentado. Ao que sabemos, trata-se do primeiro caso onde é descrita a associaçäo entre tal displasia e carcinoma espinocelular córneo-conjuntival in situ