ABSTRACT
Abstract The mechanism of the antidepressant effect of bupropion is not fully understood. Besides, using it in the treatment of depression, it is found to be effective in reducing withdrawal symptoms due to smoking cessation. A 28-year-old female patient with a history of depression was admitted to emergency department an hour after ingestion of bupropion, quetiapine, and levothyroxine in high doses to commit suicide. While accepting her into the Intensive Care Unit, she was awake, alert, disoriented and agitated. After 2 h, the patient had a generalized tonic-clonic seizure. The necessary treatment was given and 9 h later with hemodynamic improvement, the patients’ mental status improved. Bupropion may cause unusual behaviors such as delusions, paranoia, hallucinations, or confusion. The risk of seizure is strongly dose-dependent. We want to emphasize the importance of early gastric lavage and administration of activated charcoal.
Resumo O mecanismo do efeito antidepressivo de bupropiona ainda não está bem esclarecido. Contudo, seu uso no tratamento de depressão revelou ser eficaz para reduzir os sintomas de abstinência relacionados à cessação do tabagismo. Uma paciente do sexo feminino, 28 anos, com história de depressão, deu entrada no setor de emergência uma hora após a ingestão de bupropiona, quetiapina e levotiroxina em doses elevadas para cometer suicídio. Ao ser internada em unidade de terapia intensiva, estava acordada, alerta, desorientada e agitada. Após duas horas, apresentou uma crise tônico-clônica generalizada. O tratamento necessário foi administrado e nove horas mais tarde, com a estabilização hemodinâmica, o estado mental da paciente melhorou. Bupropiona pode causar comportamentos incomuns, incluindo delírios, paranoia, alucinações ou confusão mental. O risco de convulsão é altamente dependente da dose. Queremos enfatizar a importância da lavagem gástrica precoce e da administração de carvão ativado.
Subject(s)
Humans , Female , Adult , Seizures/chemically induced , Bupropion/poisoning , Antidepressive Agents, Second-Generation/poisoning , Suicide, Attempted , Thyroxine/poisoning , Antipsychotic Agents/poisoning , Epilepsy, Tonic-Clonic/chemically induced , Quetiapine Fumarate/poisoningABSTRACT
Camphor is a pleasant smelling cyclic ketone with propensity of causing neurologic side-effects especially seizures. We report two patients who after inadvertent consumption of camphor experienced an episode of generalized tonic clonic seizure. These cases highlight the importance of enquiring any intake of material (medicinal or otherwise) in every patient presenting with seizure.
Subject(s)
Adult , Camphor/administration & dosage , Epilepsy, Tonic-Clonic/chemically induced , Humans , India , Male , Medicine, Traditional , Phytotherapy/adverse effectsSubject(s)
Adult , Aminophylline/poisoning , Asthma/drug therapy , Bronchodilator Agents/poisoning , Epilepsy, Tonic-Clonic/chemically induced , Fatal Outcome , Female , Fetal Distress/chemically induced , Humans , Infant, Newborn , Maternal-Fetal Exchange , Pregnancy , Pregnancy Complications/drug therapy , Tachycardia, Supraventricular/chemically inducedABSTRACT
A case of generalised seizures following ingestion of 20 cc of endosulphan (Endocel), an organochloride insecticide is presented. The patient, a young male of 25 years made a complete recovery. The mode of action of endosulphan is due to involvement of cholinergic neuronal system and the management is on the line of status epilepticus.