Subject(s)
2,3-Diphosphoglycerate , Adenine/pharmacology , Adolescent , Adult , Anticoagulants/pharmacology , Blood Preservation , Citrates/pharmacology , Citric Acid , Diphosphoglyceric Acids/blood , Erythrocyte Aging/drug effects , Erythrocytes/drug effects , Female , Glucose/analogs & derivatives , Humans , Male , RejuvenationABSTRACT
Radioisotope red-cell survival studies were carried out in 20 patients with falciparum malaria following quinine therapy. The mean parasite clearance time of the patients receiving quinine sulfate was 49 hours and those of the patients receiving quinine sulfate and prednisolone was 46 hours. The red-cell survival was correlated with the initial hematocrit level in both groups but the daily dose of 40 mg prednisolone did not mitigate the red cell survival.
Subject(s)
Adolescent , Adult , Drug Therapy, Combination , Erythrocyte Aging/drug effects , Female , Hematocrit , Humans , Malaria/blood , Male , Middle Aged , Plasmodium falciparum , Prednisolone/therapeutic use , Quinine/therapeutic useABSTRACT
Clinical, biochemical, haematological and erythrokinetic studies were performed on 63 adult males with prolonged lead exposure. Their most common symptoms and findings were abdominal pain (62%), gingival lead lines (48%), headache and/or dizziness (33%), muscle cramps (32%), anaemia (19%), and fatigue (18%). Colicky abdominal pain (27%) and gingival lead lines correlated with urinary lead excretion. Anaemia was mild, but more frequent in the subjects with the greatest urinary lead excretion. Other associated findings were: higher reticulocyte counts and more basophilic stippling of the RBCs, more sideroblasts and greater erythroid hyperplasia of the bone marrow, more reduction in 51Cr-tagged RBC survival time, smaller RBC mass, a more rapid plasma iron clearance, a greater plasma iron turnover and greater utilization of 59Fe in subjects with urinary lead excretion of greater than 100 microng/day in comparison with the remainder and normal controls. These findings suggest that minimal chronic exposure to lead causes an increased haemolysis with resulting increased production of erythrocytes.