Subject(s)
Humans , Female , Adult , Tinea/pathology , Trichophyton/isolation & purification , Facial Dermatoses/pathology , Tinea/microbiology , Tinea/drug therapy , Biopsy , Facial Dermatoses/microbiology , Facial Dermatoses/drug therapy , Terbinafine/therapeutic use , Antifungal Agents/therapeutic useABSTRACT
Abstract Tinea faciei is a relatively uncommon dermatophyte infection entailing atypical clinical symptoms, usually misdiagnosed and treated with corticosteroids. The authors describe a case of tinea faciei on the right eyebrow caused by Trichophyton interdigitale. The patient was an 18-year-old girl, who had an inflammatory plaque with a scaly, pustular surface on the right eyebrow and upper eyelid, which had persisted for over 1 month. She was once misdiagnosed as having eczema and was treated using corticosteroid cream. A diagnosis of tinea faciei was made based on direct microscopy and culture. The sequencing of the nuclear ribosomal ITS region and β-tubulin gene of the isolate established its T. interdigitale lineage. The patient was cured by treatment with systemic terbinafine in combination with topical application of 1% naftifine-0.25% ketaconazole cream for 2 weeks.
Subject(s)
Humans , Female , Adolescent , Tinea/pathology , Trichophyton/isolation & purification , Eyebrows/microbiology , Eyebrows/pathology , Facial Dermatoses/microbiology , Facial Dermatoses/pathology , Tinea/drug therapy , Urease/analysis , Microscopy, Electron, Scanning , Treatment Outcome , Dermoscopy , Facial Dermatoses/drug therapy , Antifungal Agents/therapeutic use , Naphthalenes/therapeutic useABSTRACT
Paracoccidioidomycosis and histoplasmosis are systemic fungal infections endemic in Brazil. Disseminated clinical forms are uncommon in immunocompetent individuals. We describe two HIV-negative patients with disseminated fungal infections, paracoccidioidomycosis and histoplasmosis, who were diagnosed by biopsies of suprarenal lesions. Both were treated for a prolonged period with oral antifungal agents, and both showed favorable outcomes.
A paracoccidioidomicose e a histoplasmose são infecções fúngicas sistêmicas endêmicas no Brasil. As formas clínicas disseminadas são incomuns em pacientes imunocompetentes. Nós descrevemos dois pacientes HIV-negativos com infecções fúngicas disseminadas, paracoccidioidomicose e histoplasmose, que foram diagnosticadas por biópsias de lesões de supra-renal. Ambos foram tratados por períodos prolongados com antifúngicos orais, evoluindo com boa resposta terapêutica.
Subject(s)
Humans , Male , Middle Aged , Adrenal Gland Diseases/diagnosis , Central Nervous System Fungal Infections/diagnosis , Facial Dermatoses/diagnosis , Histoplasmosis/diagnosis , Paracoccidioidomycosis/diagnosis , Adrenal Gland Diseases/microbiology , Biopsy , Brazil , Central Nervous System Fungal Infections/microbiology , Facial Dermatoses/microbiology , Immunocompetence/physiologyABSTRACT
A zigomicose é uma doença invasiva, que acomete tanto imunocompetentes como imunocomprometidos, dependendo do tipo da cepa. O diagnóstico é clínico e histopatológico, e o tratamento é baseado em antifúngico e em limpeza cirúrgica. O presente relato de caso é sobre um menino com zigomicose rinofacial invasiva com tratamento final bem-sucedido, após terapias antifúngicas e limpezas cirúrgicas.
Zygomycosis is an invasive disease that affects both immunocompetent and immunocompromised, depending on the type of strain. This disease diagnosis is clinical and histopathological, and its treatment is based on antifungal therapy and surgical cleaning. This paper reports a case of a boy with invasive zygomycosis rinofacial who final treatment was successful after underwent antifungal and surgical therapies.
Subject(s)
Humans , Male , Child , Paranasal Sinus Diseases/microbiology , Zygomycosis/pathology , Zygomycosis/therapy , Dermatomycoses/microbiology , Facial Dermatoses/microbiology , Paranasal Sinus Diseases/pathology , Paranasal Sinus Diseases/therapy , Tomography, X-Ray Computed , Amphotericin B/therapeutic use , Treatment Outcome , Dermatomycoses/pathology , Dermatomycoses/therapy , Facial Dermatoses/pathology , Facial Dermatoses/therapy , Immunocompetence , Antifungal Agents/therapeutic useSubject(s)
Male , Cats , Humans , Animals , Aged , Facial Dermatoses/microbiology , Facial Dermatoses/pathology , Facial Dermatoses/drug therapy , Tinea/microbiology , Tinea/pathology , Tinea/drug therapy , Antifungal Agents/therapeutic use , Griseofulvin/therapeutic use , Treatment Outcome , Tinea/diagnosisABSTRACT
São descritos dois casos de zigomicose nasofacial, procedentes de Belém, PA. O achado indica não ser tão rara, como se poderia supor, pela falta de registros, a ocorrência dessa micose na Região Norte do Brasil. Em ambos os pacientes, o tratamento pelo cetoconazol determinou involução rápida das manifestações clínicas, principalmente a obstrução nasal. Com o presente relato, sobe para cinco o número de casos da infecção referidos até agora do Estado do Pará.
Two new cases of nasofacial zygomycosis from the state of Pará, Brazil, are reported. Both cases were treated with ketoconazole and the response to the drug was considered to be good; the patients improved rapidly and the nasal obstruction was the first manifestation to disappear. As five cases have been described in recent years from the state of Pará, this form of zygomycosis can no longer be considered as a rare disease in northern Brazil.