ABSTRACT
AbstractBACKGROUND:Peri-orbital dark circles are a cosmetic concern worldwide, and have been attributed to hyperpigmentation from allergy or atopic dermatitis, blood stasis, structural shadowing effects, and a thin epidermis/dermis under the eye. It is of interest to better understand lifestyle and demographic risk factors and the relative impact of melanin, blood and epidermal/dermal factors on the severity of Peri-orbital dark circles.OBJECTIVE:To compare by non-invasive imaging the impact of biological factors to a visual grading scale for Peri-orbital dark circles, and test the correlation of various demographic factors with Peri-orbital dark circles.METHODS:Subjects completed a lifestyle and health survey, and Peri-orbital dark circles severity was evaluated using standardized photographs. Hyperspectral image analysis was used to assess the contributions of melanin, blood volume, degree of blood oxygen saturation, and dermal scattering.RESULTS:Family history was the most significant risk factor for Peri-orbital dark circles. The average age of onset was 24 years, and earlier onset correlated with higher severity scores. Asthma was significantly associated with Peri-orbital dark circles scores, but self-reported allergy was not. In this study, sleep was not correlated with Peri-orbital dark circles scores. Hyperspectral imaging indicated that melanin was the dominant correlate for Peri-orbital dark circles severity, while oxygen saturation was secondary. The difference between under-eye and cheek measurements for ΔL*and ΔE* were the most significant instrumental parameters correlated with visual assessment of Peri-orbital dark circles severity.CONCLUSION:Although typically associated with lack of sleep, risk of Peri-orbital dark circles is primarily hereditary. The main factors contributing to the appearance of Peri-orbital dark circles are melanin and (deoxygenated) blood.
Subject(s)
Adolescent , Adult , Aged , Female , Humans , Middle Aged , Young Adult , Eye Diseases/etiology , Facial Dermatoses/etiology , Hyperpigmentation/etiology , Life Style , Age Distribution , Age Factors , Brazil , Eye Diseases/physiopathology , Facial Dermatoses/physiopathology , Hyperpigmentation/physiopathology , Melanins/analysis , Orbit , Oxygen/blood , Risk Factors , Severity of Illness Index , Spectrophotometry , Statistics, Nonparametric , Skin/physiopathologySubject(s)
Humans , Female , Facial Dermatoses/etiology , Adrenal Cortex Hormones/adverse effects , Contraceptives, Oral/adverse effects , Cosmetics/adverse effects , Diagnosis, Differential , Facial Dermatoses/drug therapy , Facial Dermatoses/pathology , Facial Dermatoses/physiopathology , Prognosis , Signs and SymptomsABSTRACT
Se reporta el caso de una mujer de 49 años con lesiones purpúricas diseminadas de aparición súbita y pruebas de coagulación normales. El cuadro se instaló después de intervención quirúrgica porcarcinoma cervico-uterino; hubo resolución con presencia de secuelas
Subject(s)
Humans , Female , Middle Aged , Facial Dermatoses/diagnosis , Facial Dermatoses/physiopathology , Leg Dermatoses/physiopathology , Purpura/physiopathology , Uterine Cervical Neoplasms/surgery , Leg Dermatoses/diagnosis , Protein C/deficiency , Purpura/drug therapyABSTRACT
Se presenta el caso de una mujer de 20 años con lesiones granulomatosas periorbitarias, asintomáticas de diez años de evolución. La histología mostró un infiltrado granulomatoso con intensa eosinofilia. La paciente respondió excelentemente a la diamino difenil sulfona. Se comenta la rareza de esta entidad, la inusual morfología de las lesiones y la notable respuesta a la DDS