ABSTRACT
Statins and fenofibrate are the most effective pharmacological agents used to treat hyperlipidemia. Better understanding of various pleotropic effects of statins and fenofibrate have prompted a new surge of interest in their use to treat or prevent a wide range of chronic and life-threatening disorders. Male Swiss albino mice were treated with either heat killed E. coli or saline. They were classified into 14 groups. The effects of simvastatin and fenofibrate ill with a low and a high triton dose [200 and 400 mg/kg /three times weekly for 3 weeks] on the levels of interferon-gamma [IFN-gamma], total immunoglobulins and total antioxidant activity were examined in both normal and immunized mice. Simvatatin and fenofibrate administration together with the low or high triton dose or triton alone, induced a significant rise in the level of interferon-gamma [IFN- gamma] and total immunoglobulins in immunized animals as compared to non-immunized ones. Moreover, there was all in the total antioxidant activity upon treatment with either simvastatin or fenofibrate in non-immunized and immunized hyperlipidemic mice. In conclusion, these findings revealed that treatment with low or high dose triton in combination with either simvastatin or fenofibrate increased the acquired immunity by increasing the level of interferon- gamma and total immunoglobulins. In addition, these combinations also increased the antioxidant activity during infection