ABSTRACT
Active immunization with chicken egg white thiamin carrier protein (TCP) was performed to assess the functional importance of the vitamin carrier during gestation in rats. Towards this, fertile female rats were immunized with heterologous TCP and when the circulatory titres of anti-TCP IgG were high, these animals were mated with fertile male rats. Progression of pregnancy was monitored by measuring circulatory progesterone levels. A sudden fall in the steroid hormonal levels around day 8 post coitus was observed. Histological examination of the uterine tissue sections on day 7 revealed that active immunization with TCP affected the blastocyst viability resulting in unsuccessful implantation and hence pregnancy termination.
Subject(s)
Animals , Carrier Proteins/immunology , Chickens , Egg Proteins/immunology , Embryo Implantation , Female , Fetal Death/immunology , Male , Pregnancy , Rats , Rats, Wistar , ThiamineSubject(s)
Humans , Female , Fetal Death/immunology , Carcinoembryonic Antigen/analysis , Amniocentesis , Cell BiologySubject(s)
Humans , Female , Pregnancy , Infant, Newborn , Infant , Fetal Death/complications , Fetal Death/diagnosis , Fetal Death/immunology , Fetal Death/pathology , Fetal Death/therapyABSTRACT
Os autores conceituam a sindrome antifosfolipide abordando aspectos sobre seu diagnostico bem como sua relacao com historia de perdas fetais de repeticao, particularmente no segundo e terceiro trimestre de gravidez. Analisam os possiveis tratamentos e as perspectivas futuras das gestantes portadoras de anticorpos antifosfolipides.