ABSTRACT
OBJECTIVE: To evaluate the incidence and volume of feto-maternal hemorrhage following cordocentesis. STUDY DESIGN: Descriptive study. MATERIAL AND METHOD: One hundred and sixteen asymptomatic non-anemic pregnant women with an indication for cordocentesis at 18-22 weeks of gestation between January and June 2004 were recruited. Maternal blood samples were obtained immediately before and 30 minutes after cordocentesis. Fetal cells in the maternal blood were counted using Kleihauer Betke test. About 25,000 maternal cells per slide were scanned by the same examiner. Feto-maternal hemorrhage was considered significant if the fetal bleeding was more than 0.25 ml. RESULTS: There was a significant increase in fetal blood volume in maternal circulation after cordocentesis (Paired Students t test, p < 0.001). A significant hemorrhage (> 0.25 ml) occurred in 63 from 116 women (54. 7%). Only one had marked hemorrhage of more than 5.0 ml and none had massive hemorrhage (> 15 ml). CONCLUSION: Cordocentesis at 18-22 weeks of gestation can be associated with feto-maternal hemorrhage in more than half of the cases but nearly all cases had only minimal hemorrhage and none had massive hemorrhage.
Subject(s)
Adolescent , Adult , Cordocentesis/adverse effects , Female , Fetomaternal Transfusion/epidemiology , Humans , Incidence , Middle Aged , Pregnancy , Pregnancy Trimester, Second , Thailand/epidemiologyABSTRACT
Feto-maternal transfusion was studied in 2,000 pregnant Thai women. The technic used in the study was modified acid election test. The population were divided into five group, first trimester, second trimester, third, during delivery and non pregnant women. Over all fetomaternal transfusion occurred in 1,055 women (65.94%). In first trimester, second trimester, third trimester and during delivery were 53.5 per cent, 63.0 per cent, 71.1 per cent and 75.7 per cent respectively. The data were significantly different from non pregnant women (p < 0.0001). The volume of transfusion was varied from 0 to 12.65 ml and greater in the advancing gestational age. In first trimester, second trimester, third trimester and during delivery the volume of transfusion were 0.07, 0.08, 0.13, 0.19 ml respectively.