ABSTRACT
La Demencia Lobar Fronto Temporal (DFTL) variante frontal suele ser subdiagnosticada por presentar síntomas psiquiátricos y preservación de la memoria hasta etapas muy avanzadas de la enfermedad. Se inicia durante la mediana edad con trastornos conductuales, afectivos y del habla. Frecuentemente es tratada erróneamente como trastorno depresivo, esquizofrenia o psicosis funcional durante las primeras fases. Es la 3ra causa de demencia degenerativa y la 2da causa en menores de 65 años. Es por ello que considero importante el tener en cuenta su diagnóstico y diagnósticos diferenciales con patologías psiquiátricas y también orgánicas como la del Cerebro Hundido (FBSS) que suele diagnosticarse como DFTL. Se abordan las definiciones, prevalencia, incidencia, factores de riesgo, genética, clasificaciones, criterios diagnósticos, diagnósticos diferenciales y abordajes terapéuticas
Frontotemporal Dementia (FTD) with frontal variant is usually underdiagnosed for presenting psychiatric symptoms and the preservation of memory until very advanced stages of the disease. Its onset is during midlife with behavioral, affective and speech disorders. it is frequently mistreated as depressive disorder, schizophrenia or functional psychosis during the first phases. It's the third cause of degenerative dementia and the second cause among people below 65 years-old. This is why I consider it important to take into consideration its diagnosis and differential diagnoses with sychiatric as well as organic pathologies such as the "Sagging Brain" which is usually diagnosed as FTLD. This article includes definitions, prevalence, incidence, risk factors, genetics, classifications, diagnostic criteria, differential diagnoses and therapeutic approch
Subject(s)
Middle Aged , Aged, 80 and over , Diagnosis, Differential , Frontotemporal Dementia/classification , Frontotemporal Dementia/diagnosis , Frontotemporal Dementia/etiology , Risk Factors , Affective Symptoms/pathology , Therapeutics , Tauopathies/diagnosis , Tauopathies/pathology , Language Disorders/pathologyABSTRACT
Background: Front temporal dementias (FTD) are neurodegenerative disorders characterized by alterations in behavior, affection and language, with relative sparing of episodic memory. There are three major forms of FTD: the frontal or behavioral form, progressive non-fluent aphasia and semantic dementia (that may begin as a fluent progressive aphasia). Aim: To report a retrospective clinical experience of patients with frontotemporal dementia. Material and methods: Review of 3,700 records of neuropsychological assessments of patients with behavioral disturbances, studied between 1981 and 2008. Of these, 63 patients (59 percent females) complied with the criteria for frontotemporal dementia. Results: There were 47 cases with the frontal variant, four with non-fluent progressive aphasia and six with fluent progressive aphasias (2 evolved to semantic dementia). The mean age of onset was 60±11 years. There were no familiar cases of FTD. Conclusions: It is clinically difficult to diagnose FTD, since evaluation of attitude or language is required. In addition to structural images, functional images were helpful in some cases, but the definitive diagnosis is anatomical.