ABSTRACT
We review the present knowledge of serum fucose with special attention to its relation with various malignant diseases. We summarize the role of serum fucose as a useful diagnostic and prognostic marker when used singly or in combination. The purpose of this review is to provide an expert opinion on the practical and applied aspect of serum fucose level in clinical practice and research settings. Our review is based on information from published research studies, library books, and electronic searches through Medline and PubMed. The available published data were used as the basis for recommendations. Each of the subsections concludes to provide information to assist the clinicians and the research scientists make informed decisions.
Subject(s)
Fucose/blood , Humans , Neoplasms/blood , Prognosis , Biomarkers, Tumor/bloodABSTRACT
Serum fucose and sialic acid levels were determined in 50 oral cancer patients and 25 healthy controls. A statistically significant increase was noted in the study group. The increase in serum fucose level correlated well with the clinical staging in the study group whereas sialic acid did not. These values were independent of age, sex and histopathological grading. The result suggest that the serum fucose level is a better biochemical tumor marker than sialic acid level. However its usefulness may be limited if used judiciously to assess the prognosis of the disease.
Subject(s)
Adult , Aged , Carcinoma, Squamous Cell/blood , Female , Fucose/blood , Humans , Male , Middle Aged , Mouth Neoplasms/blood , N-Acetylneuraminic Acid/blood , Neoplasm StagingABSTRACT
Serum protein bound fucose levels and the ratio between serum protein bound fucose and total serum protein were determined in 40 healthy females, 60 patients with benign gynaecological disorders and 50 patients with previously untreated cases of carcinoma cervix. The mean serum fucose level in healthy subjects was 8.96 mg% and the ratio between serum protein bound fucose and total serum protein was 1.29 x 10(-3). Mean serum fucose level in patients with benign gynaecological disorders was 9.42 mg% and the ratio between serum protein bound fucose and total serum protein was 1.42 x 10(-3). In stage I and II carcinoma cervix patients mean serum fucose was 11.92 mg% and the ratio between serum protein bound fucose and total serum protein was 1.68 x 10(-3). In stage III and IV carcinoma cervix patients the mean serum fucose was 17.76 mg% and the ratio between serum protein bound fucose and total serum protein was 2.64 x 10(-3).
Subject(s)
Blood Proteins/analysis , Carcinoma/blood , Female , Fucose/blood , Genital Diseases, Female/blood , Humans , Neoplasm Staging , Uterine Cervical Neoplasms/bloodABSTRACT
Con el propósito de conocer los niveles séricos de ácido siálico, 1-fucosa y fucosidasa, se cuantificaron sus valores en 107 adultos (25 a 90 años) sometidos a endoscopia oral. Con los resultados obtenidos se analiza su utilidad como método de pesquisa en el diagnóstico de cáncer gástrico. La muestra estudiada estuvo integrada por cuatro grupos: sin alteraciones endoscópicas (n=25); úlcera duodenal (n = 25); úlcera gástrica (n = 25) y cáncer gástrico (n = 32). Los valores promedio obtenidos para el ácido siálico fueron: 1,96; 1,19; 20,5 y 2,80 micronmol/ml; para la 1-fucosa: 9,32; 9,00; 10,8 y 13,0 mg/dl y para la actividad fucosidasa: 11,5; 10,2; 9,06 y 10,6 U/l respectivamente. El coeficiente de correlación ácido siálico-1-fucosa fue 0,80 (p < 0,01) en los grupos sin alteración y cáncer gástrico. La fucosidasa no tuvo variaciones significativas entre los diferentes grupos estudiados. Las determinaçöes de ácido siálico y 1-fucosa presentaron una sensibilidad del 81 y 74% respectivamente en pacientes portadores de cáncer gástrico pero ella fue de 97% cuando se consideran pacientes que tienen ácido siálico o 1-fucosa positivos. Porcentajes importantes de pacientes sin alteraciones endoscópicas o con otras afecciones gástricas cursan con valores positivos de ácido siálico y 1-fucosa. Por tratarse de procedimientos simples y sensibles, las ácido siálico y 1-fucosa. Por tratarse de procedimientos simpsles y sensibles, las determinaciones séricas de ácido siálico y 1-fucosa pudiera ser de utilidad para la detección de cáncer gástrico o de su control evolutivo