novel synthesis of furocoumarin sulphur analogues

In the present work, a novel method for the synthesis of 7-thiocarboxamidothieno [3',2',6,7] [I] benzopyran-8-one and 8-thiocarboxamidothieno [3',2',6,7] [I] benzopyran-7-one, is reported. The appropriate aldehydes were treated with cyanothioacetamide in presence of triethylamine where the products were subjected to acid hydrolysis to give the desired compounds. The chemical structures of the title compounds and their intermediates were confirmed by studying their spectral data. The biological activity of the prepared furanocoumarin sulfur analogues is under study

Synthesis and molluscicidal activity of some furo [2,3,-d] pyrimidine and furo [2,3-b] pyridine derivatives

In the last few years we have been involved in a program aiming to develop new simple approaches for synthesis of heteiecyclic systems of expected biological potentialities from laboratory available starting materials [1,3]. Since Schistomiasis is a national health problem in Egypt, we tried to synthesize antischistosomiasal condensed furans. Thus, while phenarylmalononitrilt 1 [4] has afforded furan-3-carboxamide derivative upon reflux in acetic-sulphuric acid mixture [5], the furan-3-carbonitrile derivative 2 [Scheme 1] was obtained in almost quantitative yield by re fluxing 1 in ethanol catalysed by triethylamine; mp. 199-200degree Iit.l98 degree] [6]