ABSTRACT
Gallbladder cancer is a rare disease in Western developed countries, but it is a highly prevalent and lethal disease in Chile and other countries in Latin America. No randomized controlled trials have been performed in gallbladder cancer to establish standard treatments. We therefore performed the first Latin American consensus meeting for the management of gallbladder cancer. In this article we present the conclusions of the panel of experts for the palliative treatment of unresectable or metastatic gallbladder cancer based on a review of the literature, the discussion of the participating experts and the opinion of the assistants. The topics reviewed included: 1.- Gallbladder Cancer and Cholangiocarcinoma -are they the same disease?; 2. - Palliative Chemotherapy: Indications, Drugs and Schedules; 3. - Palliative Radiotherapy; 4.- Palliative Surgery; 5.-Management of Malignant Biliary Obstruction.
Subject(s)
Humans , Cholangiocarcinoma/drug therapy , Gallbladder Neoplasms/drug therapy , Palliative Care , Gallbladder Neoplasms/secondary , Latin America , Societies, MedicalABSTRACT
Gall bladder metastasis from renal cell carcinoma is rare. We report a 46-year-old man with isolated gall bladder metastasis from renal cell carcinoma 11 months after radical nephrectomy. He underwent cholecystectomy and frozen section revealed the metastatic tumor. Sixteen months later, the patient is free of disease.
Subject(s)
Carcinoma, Renal Cell/secondary , Cholecystectomy , Frozen Sections , Gallbladder Neoplasms/secondary , Humans , Kidney Neoplasms/pathology , Male , Middle Aged , Nephrectomy , ReoperationABSTRACT
Se presenta un caso de carcinoma mamario lobulillar que cinco años después presenta metástasis a vesícula biliar. La metástasis fue sospechada por el estudio histológico y confirmada por medio de inmunohistoquímica para receptores de estrógenos y progesterona.
Subject(s)
Humans , Female , Middle Aged , Carcinoma, Lobular/pathology , Gallbladder Neoplasms/etiology , Gallbladder Neoplasms/secondary , Cholangiography , Cholangiopancreatography, Endoscopic Retrograde/methodsABSTRACT
Las metástasis en aparato digestivo, extrahepático son poco frecuentes y se caracterizan por presentarse luego de un período de latencia largo que va de 3 a 20 años, sus síntomas son inespecíficos y simulan enfermedades inflamatórias o segundo tumor. El subtipo histológico más común es el carcinoma lobulillar. Presentamos dos casos de metástasis de carcinoma de mama, uno en íleo-colon y otro en vesícula biliar. Ambas pacientes comenzaron con síntomas que llevaron a diagnósticos de enfermedad de Crohn en el primero y de colecistitis aguda en el caso dos. El diagnóstico se realizó en las piezas quirúrgicas, donde se observaron células de carcinoma lobulillar que infiltraban desde la serosa hasta la mucosa inclusive y con la inmunomarcación que resultaron BCA225, Estrógeno y Progesterona positivos. El tratamiento con radioterapia, quimioterapia u hormonal, mejora la calidad de vida, pero el promedio de sobrevida luego del diagnóstico es de un año.
Subject(s)
Humans , Female , Middle Aged , Breast Neoplasms/pathology , Carcinoma, Lobular/pathology , Colonic Neoplasms/secondary , Gallbladder Neoplasms/secondary , Ileum , Intestinal Neoplasms/secondary , Acute Disease , Breast Neoplasms/diagnosis , Carcinoma, Lobular/diagnosis , Cholecystitis/diagnosis , Colonic Neoplasms/diagnosis , Crohn Disease/diagnosis , Diagnosis, Differential , Gallbladder Neoplasms/diagnosis , Intestinal Neoplasms/diagnosisABSTRACT
The authors report the case of a 63 year -old woman, with multiple jejunal metastases from a cutaneous malignant melanoma, revealed by a peritonitis. The operation revealed a metastasis of the gall bladder. By means of this case, the authors insist on the frequency of this metastasic localisation in the intestinal tract, on the usual mildness of the symptoms produced by osuch a localisation, and on the usual rapid course of malignat melanoma in the intestine