ABSTRACT
Abstract: Ecthyma gangrenosum is a rare skin infection classically associated with Pseudomonas aeruginosa. We performed a retrospective study of all cases diagnosed with ecthyma gangrenosum from 2004-2010 in a university hospital in Mexico (8 cases, 5 female patients and 3 male patients, ages between 4 months and 2 years). The most common risk factor for ecthyma gangrenosum is neutropenia in immunocompromised patients. In previously healthy patients, immunological evaluation is important to rule out underlying immunodeficiency. Ecthyma gangrenosum in healthy patients has a high mortality rate and early diagnosis and aggressive antibiotic treatment is imperative as it can improve patients' prognosis.
Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Pseudomonas aeruginosa/isolation & purification , Pseudomonas Infections/complications , Ecthyma/microbiology , Gangrene/microbiology , Retrospective Studies , Ecthyma/drug therapy , Gangrene/drug therapyABSTRACT
Inflammatory bowel diseases can commonly present many cutaneous lesions which can contribute to the diagnosis of the disease or its activity. The most frequent cutaneous or mucocutaneous manifestations suggesting ulcerative rectocolitis activity are erythema nodosum (3-10%), pyoderma gangrenosum (5-12%) and aphthous stomatitis (4%). Other reactive skin manifestations related to immunological mechanisms associated with the inflammatory bowel disease are: Sweet's syndrome, arthritis-dermatitis syndrome associated with inflammatory bowel disease and leukocytoclastic vasculitis. We describe the case of a young man with diagnosis of ulcerative rectocolitis, which presented an extensive cutaneous gangrene secondary to microvascular thrombosis. The case represents a dermatologic rarity and should be recognized as a cutaneous manifestation related to the hypercoagulability state observed in the disease's activity.
Subject(s)
Adult , Humans , Male , Inflammatory Bowel Diseases/complications , Proctocolitis/complications , Skin/pathology , Biopsy , Gangrene/drug therapy , Gangrene/etiology , Gangrene/pathology , Thrombosis/complicationsABSTRACT
Venous gangrene is a rare condition. We report a case of venous gangrene, treated successfully with thrombolytic therapy and subsequently by skin grafting.
Subject(s)
Anticoagulants/therapeutic use , Female , Fibrinolytic Agents/therapeutic use , Gangrene/drug therapy , Heparin, Low-Molecular-Weight/therapeutic use , Humans , Middle Aged , Skin Transplantation , Streptokinase/therapeutic use , Thrombolytic Therapy , Treatment OutcomeABSTRACT
Association of symmetric peripheral gangrene (SPG) with falciparum malaria infection is a relatively uncommon clinical entity. Here we report a case of complicated falciparum malaria with SPG involving both lower limbs from the mid-calf downwards, probably due to antibody mediated vasculitis.
Subject(s)
Antimalarials/administration & dosage , Child , Gangrene/drug therapy , Humans , Infusions, Intravenous , Leg/pathology , Malaria, Falciparum/complications , Male , Quinine/administration & dosageSubject(s)
Acute Disease , Adult , Anti-Bacterial Agents/therapeutic use , Child , Female , Fingers/pathology , Gangrene/drug therapy , Humans , Male , Middle Aged , Toes/pathologyABSTRACT
Os autores fazem uma revisäo sobre os aspectos farmacológicos e mecanismos de açäo da clofazimina (CFZ) de um modo geral e, em particular, sobre seus efeitos no pioderma gangrenoso (PG). É feita também uma avaliaçäo sobre os diferentes métodos de tratamento utilizados no PG. Como ilustraçäo é demonstrado o caso de uma paciente de 13 anos de idade, feminina, natural e procedente do Maranhäo, portadora de PG, que foi tratada com 200 mg diários de CFZ, obtendo remissäo total do quadro em quatro semanas
Subject(s)
Humans , Female , Adolescent , Clofazimine/pharmacokinetics , Gangrene/drug therapy , Pyoderma/drug therapy , Clofazimine/therapeutic useABSTRACT
Se analiza 5 casos de gangrena escroto peneana de Fournier tratadas por los autores, y diagnosticadas entre 7.500 operaciones de cirugía mayor en un período de 5 años. Se describen las generalidades de esta poco frecuente patología y las indicaciones terapéuticas como profilácticas más relevantes dentro del manejo quirúrgico. Se destaca a su vez la gravedad de la misma y la alta mortalidad observada en diferentes medios. Se comenta la múltiple asociación y sinergismo de agentes microbianos aeróbicos y anaeróbicos que concurren en la génesis de esta enfermedad
Subject(s)
Adult , Middle Aged , Humans , Male , Gangrene/surgery , Penile Diseases/surgery , Gangrene/drug therapy , Penis/surgery , Scrotum/surgeryABSTRACT
Se evaluó, en infecciones mixta por microorganismos aerobios y anaerobios, la eficacia y tolerancia del tratamiento combinado de Cefoperazona(2g/dia) y tinidazol (0.8g/d), administrando por via intravenosa en 36 pacientes (rango de edad 13-65 anos, 20 mujeres y 16 hombres) durante 5-17 dias (promedio 7.8 dias) con las siguientes infecciones severas: peritonitis(n=18), sepsis(n=2) abceso de pared abdominal(n=3), enfermedades inflamatoria pelviana(n=3) neumonia (n=2) colecistitis(n=1), osteomielitis(n=1), abceso subfrenico(n=3), abceso hepatico, tubo-ovarico y gangrena de miembros inferiores(1caso c/u). Los microorganismos sensibles a cefoperazona y/o tinidazol aislados fueron: E. Coli, Acinetobacter, sp., Bacteroides, sp., P.aeruginosa, k. pneumoniae, peptoestreptococcus, Enterocoicos, P.vulgaris,