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Insights into the mechanism of action of benzoyl peroxide as a tumor promoter.

Rudra, N; Singh, N.

Indian J Physiol Pharmacol ; 1997 Apr; 41(2): 109-15

Article in English | IMSEAR | ID: sea-107598

ABSTRACT

A comparison of the mechanism of action of benzoyl peroxide, a tumor promoter was studied in three different cell lines i.e. NIH 3T3, HDCS and A431. Benzoyl peroxide was found to mediate its effect by inducing poly ADP-ribosylation in all the three cell types studied but to different extents, with histone H1 serving as a common acceptor for poly ADP-ribose. It also stimulated the activities of the antioxidant enzymes CuZn superoxide dismutase and catalase in NIH 3T3 and HDCS cells, but not in A431. Alterations in the expression of c-jun and c-fos were observed in NIH 3T3 and A431 cells. Benzoyl Peroxide appeared to mediate its effect via genetic and epigenetic mechanisms.

Subject(s)

3T3 Cells/cytology , Animals , Benzoyl Peroxide/toxicity , Blotting, Northern , Carcinogens/toxicity , Catalase/metabolism , Cells, Cultured , Gene Expression Regulation, Neoplastic/drug effects , Genes, fos/drug effects , Genes, jun/drug effects , Histones , Keratolytic Agents/toxicity , Mice , Poly Adenosine Diphosphate Ribose/metabolism , Poly(ADP-ribose) Polymerases/metabolism , Protein Kinase C/metabolism , Superoxide Dismutase/metabolism , Tumor Cells, Cultured/enzymology

ABSTRACT

Subject(s)

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