Burden of genital warts in Colombia: an observational study / Carga das verrugas genitais na Colômbia: um estudo observacional

Introduction: Genital warts are benign lesions caused by sexual transmission of human papillomavirus types 6 and 11, with significant impact on healthcare resource use and patients' quality of life. Objective: To describe the epidemiology of genital warts in adults visiting a physician office for any reason, physician practice patterns, and healthcare resource use and costs in Colombia. Methods: Participants were a convenience sample of 53 physicians in 5 specialties: primary care (15), gynecology (24), urology (12), proctology (1), and dermatology (1). Physicians completed a survey and daily log of all patients 18-60 years old seen over 10 days in their practices in 2016-2017. The physician survey recorded genital warts consultation and management patterns. The daily log recorded patient demographic information and genital warts diagnosis. Results: Among 6,393 patients logged by physicians, the genital warts prevalence was 2.03% (95%CI 1.69­2.38) and incidence 1.30% (95%CI 1.02­1.58). Primary care physicians referred most of their genital warts cases for treatment (female: mean 63.3%, SD=44.8; male: mean 58.3%, SD=43.8). Treatment of non-resistant episodes (<6-month duration) lasted an average of 37.4 days (SD=29.4) and required an average of 4.0 (SD=1.9) office visits for females and 3.0 (SD=1.7) for males. The overall mean cost of an episode of care was USD558.13 (SD=507.30). Conclusion: Genital warts cases reported by most participant physicians were mainly direct-consult, but patients were typically treated by specialists. Much of the genital warts health care utilization and costs reported could be prevented by immunization with the quadrivalent or nonavalent HPV vaccine.

Introdução: As verrugas genitais são lesões benignas, de transmissão sexual, causadas pelo papilomavírus humano tipos 6 e 11 e que causam impacto significativo no uso de recursos de saúde e na qualidade de vida dos pacientes. Objetivo: Descrever a epidemiologia das verrugas genitais em adultos que buscaram atendimento médico ambulatorial por qualquer motivo, incluindo padrões de prática médica, uso de recursos de saúde e custos na Colômbia. Métodos: foi utilizada uma amostra de conveniência composta por 53 médicos em 5 especialidades: clínico geral (15), ginecologia (24), urologia (12), proctologia (1) e dermatologia (1). Os médicos completaram um questionário e registros diários de todos os pacientes com idade entre 18 e 60 anos atendidos durante 10 dias em seus consultórios em 2016-2017. O questionário registrou os padrões de prática médica e de tratamento de verrugas genitais. Os registros diários continham informações demográficas do paciente e o diagnóstico de verrugas genitais. Resultados: Entre 6.393 atendimentos médicos, a prevalência das verrugas genitais foi de 2,03% (IC95% 1,69­2,38) e a incidência de 1,30% (IC95% 1,02­1,58). Os clínicos gerais encaminharam a maioria dos pacientes com verrugas genitais para tratamento (mulheres: média de 63,3%, DP=44,8; homens: média de 58,3%, DP=43,8). O tratamento dos casos não-persistentes (<6 meses de duração) durou em média 37,4 dias (DP=29,4) e requereu uma média de 4,0 (DP=1,9) consultas para mulheres e 3,0 (DP=1,7) para homens. O custo médio geral do tratamento foi de US$ 558,13 (SD=507,30). Conclusão: Os casos de verrugas genitais relatados pela maioria dos médicos participantes derivaram-se principalmente de atendimentos primários e os pacientes foram tratados geralmente por especialistas. Grande parte da utilização de recursos e custos relacionados a verrugas genitais poderia ser evitada pela imunização com a vacina papilomavírus humano 4-valente ou 9-valente.

Incidence, psychosocial burden, and economic impact of genital warts in Mexico / Incidencia, carga psicosocial e impacto económico de las verrugas genitales en México

Abstract: Objective: To estimate the burden of genital warts (GW) in Mexico. Materials and methods: We estimated the annual incidence of GW based on data reported by specialist physicians. We also assessed GW treatment practices, the average cost of treatment, and the psychosocial burden of GW among patients. Results: The annual incidence of GW in Mexico was estimated to be 547 200 cases. Treatment procedures vary by specialist and patient gender. The estimated annual cost was $195 million USD. The psychosocial impact of GW was slightly greater in males than females. Conclusions: This is the first evaluation of the burden of GW in Mexico. Our data suggest that GW are common, with significant health-related costs and psychosocial impact.

Resumen: Objetivo: Estimar la carga por verrugas genitales (VG) en México. Material y métodos: Estimamos la incidencia anual de VG, con base en información proporcionada por médicos especialistas y el manejo de las VG, así como el costo promedio del tratamiento y la carga psicosocial de las VG. Resultados: La incidencia anual de VG en México fue de 547 200 casos. Los tratamientos variaron según la especialidad y el sexo del paciente. El costo anual por VG fue de $195 millones de dólares estadounidenses. El impacto psicosocial de las VG es ligeramente mayor en hombres que en mujeres. Conclusiones: Esta es la primera evaluación de la carga de VG en México. Los datos sugieren que las VG son frecuentes, tienen costos relacionados con salud e impactos psicosociales significativos.

Incidence of external genital lesions related to human papillomavirus among Mexican men. A cohort study / Incidencia de lesiones genitales externas relacionadas con el virus del papiloma humano entre hombres mexicanos. Un estudio de cohorte

Abstract: Objective: To determine external genital lesion (EGL) incidence -condyloma and penile intraepithelial neoplasia (PeIN)- and genital HPV-genotype progression to these EGLs. Materials and methods: Participants (healthy males 18-74y from Cuernavaca, Mexico, recruited 2005-2009, n=954) underwent a questionnaire, anogenital examination, and sample collection every six months; including excision biopsy on suspicious EGL with histological confirmation. Linear array assay PCR characterized 37 high/low-risk HPV-DNA types. EGL incidence and cumulative incidence were calculated, the latter with Kaplan-Meier. Results: EGL incidence was 1.84 (95%CI=1.42-2.39) per 100-person-years (py); 2.9% (95%CI=1.9-4.2) 12-month cumulative EGL. Highest EGL incidence was found in men 18-30 years: 1.99 (95%CI=1.22-3.25) per 100py. Seven subjects had PeIN I-III (four with HPV16). HPV11 most commonly progresses to condyloma (6-month cumulative incidence=44.4%, 95%CI=14.3-137.8). Subjects with high-risk sexual behavior had higher EGL incidence. Conclusion: In Mexico, anogenital HPV infection in men is high and can cause condyloma. Estimation of EGL magnitude and associated healthcare costs is necessary to assess the need for male anti-HPV vaccination.

Resumen: Objetivo: Determinar incidencia de lesiones genitales externas (LGE) -condiloma y neoplasia intraepitelial del pene (NIP)- y progresión de genotipos de VPH a LGE. Material y métodos: Se aplicaron cuestionarios, examen anogenital y recolección de muestras cada seis meses a hombres sanos (18-74 años, de Cuernavaca, México, reclutados 2005-2009, n=954) con biopsia y confirmación histológica. Se caracterizaron 37 tipos de ADN-VPH; se calculó incidencia de LGE (cumulativa con Kaplan-Meier). Resultados: Incidencia de LGE=1.84 (IC95%=1.42-2.39) por 100-persona-años (pa); 2.9% (IC95%=1.9-4.2) LGE acumulativa a 12 meses. Mayor incidencia de LGE entre hombres 18-30 años; 1.99 (IC95%=1.22-3.25) por 100pa. Siete sujetos tuvieron NIP I-III. VPH-11 más comúnmente progresa a condiloma (incidencia acumulativa a seis meses=44.4%, IC95%=14.3-137.8). Los sujetos con comportamiento sexual de alto riesgo tuvieron mayor incidencia de LGE. Conclusiones: En México la infección anogenital con VPH es alta y puede causar condiloma. La estimación de magnitud de LGE y los costos sanitarios asociados se necesita para evaluar la necesidad de vacunación contra VPH en hombres.

Genital prevalence of HPV types and co-infection in men

Introduction: HPV infection is a highly prevalent sexually transmitted disease and there is evidence of the relationship of HPV infection and the development of genital warts, penile intraepitelial neoplasia, invasive penile carcinoma and cervical cancer. However, there is sparse data regarding the prevalence of HPV types and co-infection of different HPV types among men. Objectives: To assess the prevalence of HPV subtypes infections and rates of co-infection among men. Materials and Methods: 366 men were evaluated from March to October 2010. Men were referred to our institution for HPV diagnostic evaluation based on the following criteria: 1. presence of a genital wart; 2. presence of an atypical genital lesion; 3. absence of symptoms and a partner with a HPV diagnosis; 4. absence of symptoms and a desire to undergo a full STD diagnostic evaluation. Genital samples were collected from the urethra, penile shaft, scrotum and anus with Digene® collection and preservation kit and submitted to HPV genotype microarray detection (Papillocheck®). All men were tested for the low-risk HPV types 6-11-40-42-43-44 and for the high-risk HPV types 16-18-31-33-35-39-45-51-52-53-56-58-59-66-68-70-73-82. Results: Of the 366 men, 11 were tested inconclusive and were excluded from the analysis. 256 men (72.1% of the men from the cohort referred to our institution) tested positive with genotype micro-array detection and 99 tested negative. The most prevalent HPV-subtypes in the studied population were 6, 42, 51 and 16. Co-infection was found in 153 men. Of those, 70 (19.7%) had a co-infection by 2 types, 37 (10.4%) by 3 types; 33 men (9.2%) by 4 types; 8 men (2.2%) by 5 types; 1 man (0.3%) by 6 types; 1 man (0.3%) by 7 types; 2 men (0.6%) by 8 types and 1 man (0.3%) by 9 types. Conclusion: The most frequent HPV types were 6, 16, 42 and 51. Co-infection was found in 59% of our patients. This information is vital to drive future public health ...

Prevalence and risk factors for scrotal lesions/anomalies in a cohort of Brazilian men ? 40 years of age / Prevalência e fatores de risco de lesões escrotais em uma população de brasileiros com idade ? 40 anos

OBJECTIVE: To estimate the prevalence of and risk factors for cutaneous lesions of the scrotum and intrascrotal lesions/anomalies among men included in a prostatic cancer screening program in a Brazilian metropolitan city. DESIGN AND SETTING: Cross-sectional study, private outpatient healthcare service. METHODS: 1731 men aged 40 years or over, participating in a prostate cancer screening program conducted by the municipal public employees' healthcare system, underwent systematic urological assessment by a single examiner. RESULTS: The prevalence of scrotal diseases in our sample was 44.7% (773/1731). Tinea cruris occurred in 203 (11.7%) of the participants, with higher risk among diabetics and lower prevalence among nonwhite individuals; scrotal tinea in eight (0.5%), with higher risk among hypertensive men; subcutaneous nodules in 12 (0.7%), especially in individuals with low schooling level; hydrocele in 283 (16.4%), with higher frequency among participants over the age of 60 years, diabetics or individuals with previous histories of nonspecific urethritis; spermatoceles in 174 (10.1%), with greater prevalence among individuals over the age of 60 years or diabetics, and lower frequency among individuals who underwent vasectomy; unilateral testicular hypotrophy/atrophy in 167 (9.7%) and bilateral hypotrophy/atrophy in 93 (5.4%), both occurring more frequently in individuals over the age of 60 years; absence of palpable testicles due to cryptorchidism in 7 (0.4%); and epididymitis/orchitis in 5 (0.3%), with higher prevalence among diabetics. No cases of cancer were identified in this sample. CONCLUSIONS: Scrotal diseases were highly prevalent in this population of Brazilian men. .

OBJETIVO: Estimar a prevalência e fatores de risco de lesões cutâneas do escroto e de lesões/anomalias intraescrotais entre participantes de programa de rastreamento para câncer de próstata em uma cidade metropolitana brasileira. TIPO DE ESTUDO E LOCAL: Estudo transversal, serviço privado de atendimento ambulatorial à saúde. MÉTODOS: 1.731 homens com idade igual ou superior a 40 anos, participantes do programa de rastreamento de câncer de próstata conduzido pelo sistema de saúde dos funcionários públicos municipais, foram submetidos à avaliação urológica sistemática por um único examinador. RESULTADOS: A prevalência de doenças escrotais nossa amostra foi de 44.7% (773/1731). Tinea cruris ocorreu em 203 (11,7%) dos participantes, com maior risco em diabéticos e menor prevalência em indivíduos não brancos; tinea escrotal em oito (0,5%), com maior risco em homens hipertensos; nódulos subcutâneos em 12 (0,7%), especialmente em indivíduos com baixa escolaridade; hidrocele em 283 (16,4%), com maior frequência nos participantes com mais de 60 anos, diabetes ou história prévia de uretrite inespecífica; espermatoceles em 174 (10,1%), com maior prevalência acima dos 60 anos de idade ou com diabetes, e menor frequência naqueles submetidos a vasectomia; hipotrofia/atrofia testicular unilateral em 167 (9,7%) e hipotrofia/atrofia bilateral em 93 (5,4%), ambas ocorrendo mais frequentemente nos indivíduos com mais de 60 anos; ausência de testículos palpáveis devido à criptorquidia em 7 (0,4%); e epididimite/orquite em 5 (0,3%), com prevalência aumentada em diabéticos. Não foram identificados casos de câncer nesta amostra. CONCLUSÕES: As doenças escrotais foram altamente prevalentes nesta população ...

Verrugas anogenitales y sospecha de abuso sexual infantojuvenil / Anogenital warts and suspicion of child sexual abuse

El presente trabajo se refiere a las lesiones por verrugas anogenitales producidas por el virus de papiloma humano (HPV) en niños. Describe el diagnóstico, la epidemiología, los modos de transmisión, los diagnósticos diferenciales y su relación con el cáncer a largo plazo; también, la presencia de verrugas anogenitales como indicador de abuso sexual infantojuvenil. Finalmente, incluye sugerencias para el pediatra en el manejo de estos pacientes y sus familias.

This article deals with anogenital warts (AGW) injuries caused by human papiloma virus (HPV) in children. Diagnosis, epidemiology, modes of transmission, differential diagnosis, relationship between AGW and cancer are descript. Also, it remarks the presence of AGW as indicator of child sexual abuse. Finally, it includes suggestions for the management of patients and their families by the paediatrician.

Pseudotumor fibroso calcificado del cordón espermático / Calcified fibrous pseudotumor of spermatic cord

Los tumores paratesticulares son infrecuentes y la mayoría benignos. Se presenta el caso de un paciente de 24 años de edad, con antecedentes de buena salud que asistió a la consulta por notarse en el escroto derecho un tumor de aproximadamente 4 cm de diámetro, de consistencia dura e indoloro, de unos 6 meses de evolución. El ultrasonido escrotal reveló una lesión heterogénea y bien circunscrita, independiente del epidídimo y del testículo. La biopsia aspirativa con aguja fina fue infructuosa por la dureza del tumor. Se realizó una inguinotomía y la exéresis total del tumor con biopsia por congelación, negativa de malignidad. El informe histopatológico definitivo fue: pseudotumor fibroso calcificado del cordón espermático. La evolución del paciente ha sido satisfactoria. Se confirma la importancia de la inguinotomía para el abordaje de los tumores paratesticulares, más aún cuando la biopsia aspirativa con aguja fina no es concluyente para el diagnóstico(AU)

Paratesticular tumors are infrequent and most are benigns. This a case presentation of a patient aged 24 with a history of good health coming to our consultation by presence of a hard and painless 4 cm tumor in right scrotum with a 6 months course. Scrotal ultrasound (US) showed a well circumscribed heterogeneous lesion separate of epididymis and the testis. Fine needle aspiration biopsy (FNAB) was not possible by hardness of tumor. A inguinal surgery was performed and the total tumor exeresis using freezing biopsy negative of malignancy. Final histopathological report was: calcified fibrous pseudotumor of spermatic cord. Patient's course has been satisfactory. Significance of inguinal surgery was confirmed for the paratesticular tumor approach, even more when FNAB it is not conclusive for diagnosis(AU)

National study of reproductive tract infections among high risk groups of Lahore and Karachi

To estimate the prevalence of reproductive tract infections [RTIs] among the Female Sex Workers [FSWs], Male Sex Workers [MSWs], Injecting Drug Users [IDUs] and truck drivers. Cross-sectional. Lahore and Karachi, from March to August, 2004. Four hundred FSWs, 400 MSWs, 200 eunuchs, 400 IDUs and 400 truck drivers were interviewed and examined. Biological testing included PCR and ELISA. The mean prevalence of syphilis was 17.7% [95% CI: 15.1-20.3%]. Genital gonorrhoea was found among 0.8-12.3% of subjects with mean of 4.5% [95% CI: 0.8-5.2%]. Genital chlamydia was seen in 0.2-11% individuals with mean of 2.6% [95% CI: 2.1-3.1%]. Trichomonas was present in 19.3% FSWs of Lahore and 5.52% FSWs of Karachi. Only 0.8% truckers in Lahore had trichomonas. In Lahore, 47.6% FSWs and in Karachi, 27.4% FSWs were positive for bacterial vaginosis. A vast majority of IDUs, 91.8% in Lahore and 87% in Karachi were hepatitis C positive. The prevalence of syphilis is very high among all high-risk groups; particularly so among eunuchs [60.2% in Karachi and 32.3% in Lahore]. Such a high levels of RTIs indicate a serious threat for HIV epidemic because of socially transmitted infection

Prevalence of groin hernia and penoscrotal disorders in elementary-school boys in Khoramabad, 2001-2

Inguinal hernia and symptomatic genital diseases are common surgical problem. Late diagnosis and treatment of these abnormalities can lead to irreversible complications such as intestinal strangulation, infertility and psychosomatic problems. Most of these disorders can be diagnosed during childhood period.As a cross-sectional study, 3205 elementary school boy students have been examined.Abnormalities were detected in 213 children [6.6%]. 78[2.4%] had inguinal hernia, 28[0.9%] had hydrocele, 75[2%] had undescended testis and 25[0.8%] had hypospadiasis. Meanwhile, two cases of epispadiasis, one case of varicocele and three cases of micropenis were also reported. Ambiguous genitalia and apenia were not seen in our subjects. Most of the parents were not alert about their children's anomalies.According to the high incidence of penoscrotal anomalies and low public knowledge, educational and screening programs are recommended

A comparison of prevalence rates of genital ulcers among persons attending a sexually transmitted disease clinic in Jamaica

Two cross-sectional surveys were undertaken, from December 1982 to August 1983 and from November 1990 to January 1991, to estimate the prevalence rates of genital ulcer disease (GUD) in all patients presenting with a new sexually transmitted disease (STD) complaint to the STD clinic at the Comprehensive Health Centre in Kingston, Jamaica. Diagnosis of syphilis and human immunodeficiency virus (HIV) infection was based on results of laboratory tests, but diagnosis of other STDs was based on clinical features. Data from these two surveys were compared, and reported national annual incidence data for GUD reviewed. In 1982/83 6.8 percent of 23,050 patients had GUD, men (9.3 percent) more often than women (4.2 percent; p < 0.001). In 1990/91 the prevalence rate was 12.8 percent with increased rates for both men (18.2 percent) and women (6.8 percent; p < 0.001). In patients with GUD, a clinical diagnosis of genital herpes was made, in 1982/83 and 1990/91, respectively, in 16.8 percent and 7.8 percent of the patients; syphilis, in 12.9 percent and 18.8 percent; chancroid, in 12.4 percent and 13.3 percent; viral warts, in 5.7 percent and 6.3 percent; lymphogranuloma venereum, in 4.1 percent and 3.9 percent; and granuloma inguinale, in 3.6 percent and 2.3 percent. In men the rate for syphilis was 19 percent in 1990/91 and 8 percent in 1982/83 (p=0.001); and for genital herpes it was 7 percent in 1990/91 and 17 percent in 1982/83 (p=0.025). These reversals were attributed to intense media coverage of herpes in 1982/83. There was no difference in prevalence rates between the two surveys for these diseases in women, or for lymphogranuloma venereum, granuloma inguinale and genital warts in men and women. A clinical diagnosis could not be made in 44.4 percent of cases in 1982/83 (particularly in men), and in 47.6 percent of cases in 1990/91. GUDs faciltate transmission and adversely affect the prognosis of HIV. The increase in their prevalence has implications for the evolution of the local HIV epidemic, and hould be addressed effectively by stregthening the STD/HIV control programme.

Análise epidemiológica da patologias genitais associadas a papilomavírus / Epidemiologic analysis of genital pathologies associated to papillomavirus

Estudando-se casos de infecçoes genitais associadas a papilomavírus em um hospital universitário, verificou-se que as patologias mais frequentes eram o condiloma acuminado e câncer epidermóide. Objetivo. Analisar a prevalência das lesoes genitais associadas a papilomavírus e distribuiçao por sexo, idade e cor. Métodos. Foram estudadas 223 pacientes atendidas no Hospital Universitário Antonio Pedro, estado do Rio de Janeiro, durante os anos de 1988 a 1992. Após diagnóstico clínico, biópsias das pacientes foram submetidas a análise histológica. Resultados. Os resultados mostraram que, entre as doenças do trato genital associadas a papilomavírus, o condiloma acuminado e o carcinoma epidermóide eram as mais frequentes. Os casos de carcinoma epidermóide mantiveram prevalência estável ao longo do período, enquanto que o número de casos condiloma acuminado aumentou de três para 33 por ano. As duas patologias foram mais frequentes em indivíduos de cor branca. Nao houve diferença significativa entre sexo e presença de condiloma. A média de idade para carcinoma epidermóide nao sofreu variaçao significativa no período estudado, enquanto decaiu para o condiloma acuminado nos períodos de 1988 para 1989 e de 1991 para 1992. Conclusao. As lesoes genitais associadas a papilomavírus aumentaram significativamente no período de cinco anos. Maior atençao deve ser dada as campanhas de controle de diagnóstico precoce.

Afección genital / Genital disease

Se comunica la frecuencia de la gran diversidad de alteraciones de la región genital tratadas en el servicio de urología y nefrología del Hospital General de México. Para ello se revisaron 410 pacientes con afección genital benigna y maligna; de éstos 363 individuos se atendieron en el departamento de cirugía ambularorio y el resto requirió hospitalización. Los trastornos de la región genital en ocasiones son tan evidentes que los pacientes esperan que el médico descubra inmediatamente la causa e instaure un tratamiento. En Medicina existe un axioma que dice; el tratamiento se basa en un correcto diagnóstico. Esta omisión puede prolongar las molestias, favorecer el desarrollo de desfiguraciones y algunas veces conducir a una generalización irreversible de la afección. La afección de la region genital, motivo frecuente de consulta en el servicio de urología y nefrología del Hospital General de México, SS, en la mayoría de los casos es tratada en el departamento de cirugía ambulatoria. Las lesiones neoplásicas y otras que por sus características es necesario efectuar estudios de laboratorio y gabinete refinados, requieren de hospitalización del enfermo para lograr un tratamiento adecuado.