ABSTRACT
Administration of aqueous extract of T. aestivum (200 and 400 mg/kg/day, po, for 30 days) and risedronate (20 mg/kg, sc, five times a week for 30 days) following methyl prednisolone sodium succinate (10 mg/kg, sc, thrice a week for 4 weeks) induced osteoporosis in Wistar rats showed an increase in the serum levels of bone mineral content markers, decrease in the serum and urinary levels of bone resorption markers. An incline in strength of femur and tibia was seen particularly with 400 mg/kg of T. aestivum. Maintenance of calcium homeostasis, formation of collagen and scavenging of free radicals can plausibly be the mode of action of aqueous extract of T. aestivum thereby combating osteoporosis induced by glucocorticoids.
Subject(s)
Animals , Bone Density/drug effects , Bone Resorption/drug therapy , Bone Resorption/metabolism , Collagen/biosynthesis , Etidronic Acid/administration & dosage , Etidronic Acid/analogs & derivatives , Femur/drug effects , Femur/metabolism , Free Radical Scavengers/administration & dosage , Glucocorticoids/toxicity , Male , Osteoporosis/chemically induced , Osteoporosis/drug therapy , Osteoporosis/pathology , Plant Extracts/administration & dosage , Plant Extracts/chemistry , Prednisolone/administration & dosage , Rats , Tibia/drug effects , Tibia/metabolism , Triticum/chemistryABSTRACT
Administration of 3 mg/kg body weight of dexamethasone from day 1 or 3 to 7 of pregnancy did not prevent implantation in albino rats. But the same dose when administered from day 8 to 11 resulted in complete abortion / resorption in all rats. Administration of 2 mg / kg body weight of dexamethasone from day 8 to 11 of pregnancy held no effect on the foetal survival. The results indicate that a high dose of dexamethasone does not affect implantation but the same dose affects the more advanced stages of pregnancy.