Subject(s)
Humans , Male , Female , Aged , Ferric Compounds/adverse effects , Iron Salts/adverse effects , Ferrosoferric Oxide/adverse effects , Glucaric Acid/adverse effects , Gluconates/adverse effects , Anaphylaxis/etiology , Iron-Dextran Complex/adverse effects , United States/epidemiology , Ferric Compounds/administration & dosage , Risk , Ferrosoferric Oxide/administration & dosage , Ferric Oxide, Saccharated , Glucaric Acid/administration & dosage , Gluconates/administration & dosage , Anaphylaxis/epidemiology , Injections, Intravenous , Iron-Dextran Complex/administration & dosageABSTRACT
OBJECTIVE: Intravenous infusion of crystalloid solutions is a cornerstone of the treatment of hemorrhagic shock. However, crystalloid solutions can have variable metabolic acid-base effects, perpetuating or even aggravating shock-induced metabolic acidosis. The aim of this study was to compare, in a controlled volume-driven porcine model of hemorrhagic shock, the effects of three different crystalloid solutions on the hemodynamics and acid-base balance. METHODS: Controlled hemorrhagic shock (40 percent of the total blood volume was removed) was induced in 18 animals, which were then treated with normal saline (0.9 percent NaCl), Lactated Ringer's Solution or Plasma-Lyte pH 7.4, in a blinded fashion (n = 6 for each group). Using a predefined protocol, the animals received three times the volume of blood removed. RESULTS: The three different crystalloid infusions were equally capable of reversing the hemorrhage-induced low cardiac output and anuria. The Lactated Ringer's Solution and Plasma-Lyte pH 7.4 infusions resulted in an increased standard base excess and a decreased serum chloride level, whereas treatment with normal saline resulted in a decreased standard base excess and an increased serum chloride level. The Plasma-Lyte pH 7.4 infusions did not change the level of the unmeasured anions. CONCLUSION: Although the three tested crystalloid solutions were equally able to attenuate the hemodynamic and tissue perfusion disturbances, only the normal saline induced hyperchloremia and metabolic acidosis.
Subject(s)
Animals , Male , Acid-Base Equilibrium/drug effects , Hemodynamics/drug effects , Isotonic Solutions/adverse effects , Shock, Hemorrhagic/drug therapy , Disease Models, Animal , Epidemiologic Methods , Gluconates/adverse effects , Hydrogen-Ion Concentration , Isotonic Solutions/classification , Magnesium Chloride/adverse effects , Potassium Chloride/adverse effects , Swine , Shock, Hemorrhagic/chemically induced , Sodium Acetate/adverse effects , Sodium Chloride/adverse effectsABSTRACT
Se realiza un estudio comparativo de la eficacia curativa en la leishmaniasis cutánea entre el metronidazol y el pentostan, antimonio pentavalente reconocido para esta dolencia, pero no exento de efectos secundarios. Se analiza la posible influencia del tiempo de evolución de las lesiones al inicio del tratamiento con ambas modalidades terapéuticas, así como la reducción del área media de las lesiones a los 30 días de comenzado el tratamiento. En esta revisión bibliográfica efectuada se pone de manifiesto el controvertido efecto terapéutico sobre esta enfermedad exótica