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1.
Int. j. cardiovasc. sci. (Impr.) ; 34(4): 486-489, July-Aug. 2021. tab, graf
Article in English | LILACS | ID: biblio-1286836

ABSTRACT

Abstract Swyer syndrome is one of the disorders of sexual differentiation. Previous studies have demonstrated increased sympathetic activity with heart rate variability (HRV) analysis with decreasing estradiol levels. One patient presented a pure 46, XY gonadal dysgenesis with female phenotype. Cardiac autonomic modulation was assessed through HRV analysis while at rest. This research analyzed linear and nonlinear indexes. HRV analysis showed reduced parasympathetic and global modulation with an apparent increase in sympathetic tone and a loss of HR fractal dynamics toward correlated behavior, characterized by low entropy and high determinism of time series.


Subject(s)
Humans , Female , Middle Aged , Cardiovascular Diseases/complications , Gonadal Dysgenesis, 46,XY/complications , Progestins/therapeutic use , Linear Models , Nonlinear Dynamics , Hormone Replacement Therapy , Estrogens/therapeutic use
2.
Journal of Korean Medical Science ; : 380-384, 1993.
Article in English | WPRIM | ID: wpr-41124

ABSTRACT

Gonadoblastoma and dysgerminoma developed in a 24-year-old phenotypic female patient with 46,XY pure gonadal dysgenesis. This patient presented with primary amenorrhea. Clinical characteristics showed a typical stigmata of gonadal dysgenesis: primary amenorrhea, sexual infantilism, a small uterus and bilateral streak gonads. A 46,XY karyotype was made by lymphocyte culture. The patient was counseled to undergo a prophylactic bilateral gonadectomy, but she refused. Three years and three months after the initial diagnosis she felt a growing pelvic mass. Bilateral gonadectomy and total hysterectomy were performed. Histological examination revealed gonadoblastoma and dysgerminoma on both gonads. After surgery the patient received radiation therapy and also was started on hormone replacement therapy. Two years and two months after treatment by surgery the patient is well and free of recurrence.


Subject(s)
Adult , Female , Humans , Dysgerminoma/etiology , Gonadal Dysgenesis, 46,XY/complications , Gonadoblastoma/etiology , Ovarian Neoplasms/etiology
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