ABSTRACT
This study included 64 women underwent controlled ovarian hyper stimulation and ICSI. Patients were prospectively randomized to receive either urinary hMG or r-FSH for controlled ovarian hyper stimulation after a long protocol of pituitary down-regulation was achieved in all patients by giving analogues on day 21 of the menstrual cycle. The main endpoint was ongoing pregnancy rate following one treatment cycle. Secondary outcomes included total dose and cost of gonadotropin used, cycle cancellation due to poor response, number and quality of oocytes collected, fertilization rate, embryos transferred and adverse effects; ovarian hyper stimulation syndrome, multiple pregnancy and abortion rates. The results revealed that there was insufficient evidence of significant statistical difference between hMG and FSH in clinical ongoing pregnancy rate. Furthermore, there was no difference on any of the secondary outcomes. However, the cost of a treatment cycle was 47% cheaper in hMG group than in FSH group
Subject(s)
Humans , Female , Ovulation Induction , Gonadotropins/urine , Follicle Stimulating Hormone , Luteinizing Hormone , Prospective StudiesABSTRACT
A atividade endócrina relacionada com os órgäos sexuais foi avaliada em mulheres menopausadas e pós-menopausadas, antes e depois da ressecçäo cirúrgica bilateral dos ovários. Comparando os valores urinários das gonadotrofinas dos 17-cetoesteróides e estrogênios, comprova-se uma persistente atividade endócrina nos ovários senis
Subject(s)
Humans , Female , Middle Aged , 17-Ketosteroids/urine , Estrogens/urine , Genitalia/metabolism , Gonadotropins/urine , Ovariectomy , Postmenopause/metabolismABSTRACT
Se estudiaron 48 casos de telarquia prematura cuyas edades de consulta fluctuaron entre 1 mes y 8 años. Se realizó historia clínica, examen antropométrico, evaluación de grado de desarrollo mamario (según Tanner) y exámenes de Laboratorio:Rx. de cráneo E.O., EEG., fondo de ojo, 17 ks, 170H, y GT en orina 24 hrs., Colpocitograma, FSH, LH y PRL plasmática por RIA. Las pacientes fueron observadas por períodos de 3 meses a 6 años 6 meses, con un promedio de 2 años 6 meses. Se encontró relación entre desarrollo mamario y la presencia de estrogenismo vaginal en más del 50% de los casos. La aceleración de la edad ósea fué un hallasgo pocofrecuente. Las concentraciones de FSH y LH plasmáticas estaban en la mayoría de los casos dentro del rango normal. No se observaron modificiones significativas de la velocidad de crecimiento ni progresión de la telarquia prematura a pubertad precoz
Subject(s)
Infant , Child, Preschool , Child , Humans , Female , Breast/growth & development , Puberty, Precocious , Age Determination by Skeleton , Estrogens/analysis , Follicle Stimulating Hormone/blood , Gonadotropins/urine , Luteinizing Hormone/blood , Vaginal SmearsABSTRACT
The precipitation reaction although related to the biological activity of gonadotrophins, is not strictly hormone specific. The interfacial ring technique can be used for qualitative and quantitative assay of gonadotrophins and as a pregnancy test, while the immunocrit technique is more suitable as a hormone assay test for extracts of urinary gonadotrophins