ABSTRACT
Abstract Objective: To determine whether mean platelet volume (MPV), platelet distribution width (PDW), and platelet count could be used as determinants of mortality following coronary artery bypass graft (CABG) surgery and patency of saphenous vein grafts (SVG). Methods: The records of 128 patients who underwent emergency or elective coronary angiography after CABG surgery, and who died at an early stage were retrospectively reviewed. Patients were divided into three groups as early death, no SVG disease (SVGD), and SVGD group. MPV, PDW, and platelet count were evaluated at different times. Results: MPV was significantly higher in the stenotic group than in the nonstenotic group (9.7±1.8 fl and 8.2±0.9 fl, P<0.05). The postoperative MPV ratio was found to be higher in the stenotic group when compared to the preoperative period (9.6±1.8 fl and 7.8±0.9 fl, P<0.05). MPV values were also found to be higher in patients who died during the early stage than in surviving patients (9.4±1.9 fl and 8.0±1.0 fl, P<0.05). There was no statistically significant difference regarding platelet count and PDW ratios between the early deaths group and surviving patients. An MPV value higher than 10.6 predicted SVGD with 85% sensitivity and 45% specificity; and an MPV higher than 7.9 predicted early death with 80% sensitivity and 68% specificity were observed. Conclusion: MPV may be a useful indicator for the prediction of SVGD and mortality following CABG surgery.
Subject(s)
Humans , Male , Female , Middle Aged , Aged , Saphenous Vein/transplantation , Coronary Artery Bypass/mortality , Mean Platelet Volume/methods , Graft Occlusion, Vascular/mortality , Graft Occlusion, Vascular/blood , Platelet Count/methods , Postoperative Period , Reference Values , Saphenous Vein/diagnostic imaging , Vascular Patency , Coronary Artery Bypass/adverse effects , Predictive Value of Tests , Reproducibility of Results , Retrospective Studies , ROC Curve , Coronary Angiography , Constriction, Pathologic , Preoperative Period , Graft Occlusion, Vascular/diagnosis , Graft Occlusion, Vascular/etiologyABSTRACT
Se realizó un análisis retrospectivo de los resultados del tratamiento quirúrgico de pacientes con isquemia crítica de miembros inferiores. Sólo se incluyeron aquellos casos en que se utilizaron puentes aortofemorales (Aof) y axilofemorales (Axf). Se revisaron los registros de 139 pacientes (59 puentes Aof y 97 Axf). Se excluyeron los pacientes con aneurismas, con cirugía vascular previa y los infectados. La decisión táctica se basó en las condiciones clínicas que suponían un riesgo operatorio elevado. La femoral superficial estaba ocluída en 129 casos (83 por ciento). Se utilizó siempre prótesis de dacron. La supervivencia global Aof: 68,02 por ciento (ES: 8,20); Axf: 43,07 por ciento (ES: 8,12); Permeabilidad primaria, Aof: 65,11 por ciento (ES: 9,32); Axf: 52,67 por ciento (ES: 9,32). Permeabilidad secundaria, Aof: 80,55 por ciento (ES: 7,57); Axf: 71,71 por ciento (ES: 8,75). Conservación miembro, Aof: 76,16 por ciento (ES: 8,11); Axf: 75,69 por ciento (ES: 8,56). Dentro de los primeros 90 días se realizaron puentes distales en el 5 por ciento de los casos por insuficiencia hemodinámica (3/59 Aof) y en el 6,18 por ciento por trombosis del injerto (6/97 Axf). Cuando no es factible realizar un estudio prospectivo por razones éticas, es posible utilizar controles históricos, aunque la información puede estar sometida a diferentes sesgos. Nuestra experiencia sugiere que: a) la permeabilidad secundaria de los puentes Axf obtenida mediante múltiples reoperaciones tiende a ser comparable a la permeabilidad primaria de los puentes aórticos y b) ambas tasas de conservación del miembro son similares