ABSTRACT
Epiphyseal extension of benign pathology is regarded as an infrequent occurrence. This observation has been attributed to anatomical and biochemical phenomenon unique to physeal cartilage. We report a retrospective series of six patients over a period of 4 years, diagnosed with benign pathologies that showed crossing of an open physeal plate by the disease. Four of these cases were infections and two were benign tumors. The patients were aged between 5 and 11 years, all of them were treated at a tertiary referral centre and followed up for a minimum period of 6 months to evaluate the progress of disease. The findings are more than just a pathological curiosity as they alter the management and surgical procedure that needs to be performed for these conditions. The recognition of the fact that benign tumors may occasionally present with transphyseal spread will prevent unjustified radical procedures that are best reserved for aggressive malignant conditions.
Subject(s)
Bone Cysts/pathology , Bone Neoplasms/pathology , Child , Child, Preschool , Chondroblastoma/pathology , Growth Plate/microbiology , Humans , Male , Neoplasm Invasiveness , Tuberculosis, Osteoarticular/pathologyABSTRACT
O Mycobacterium tuberculosis agente causador da tuberculose tem sido enfoque no cenário mundial, devido à surgimento de cepas resistentes a drogas da primeira linha de tratamento (rifampicina, isoniazida, pirazinamida e etambutol). Em 1998 foram notificadas 82.931 casos de tuberculose, e destes 22 porcento referentes ao Estado de São Paulo. A taxa de resistência a rifampicina no Brasil foi de 1,3 porcento no período de 1994 a 1997. O teste de sensibilidade é recomendado a todas as cepas isoladas com intuito de diagnosticar rapidamente cepas resistentes. Neste trabalho foi apresentada uma nova metodologia para determinação da Concentração Inibitória Mínima (CIM) de rifampicina em cepas de M. tuberculosis utilizando o bacteriófago D29...