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Indian J Biochem Biophys ; 1993 Feb; 30(1): 7-9
Article in English | IMSEAR | ID: sea-28699

ABSTRACT

The photosensitizing properties of p-nitroacetophenone (PNAP), a well-known radiosensitizer, have been studied in near UV region. The mechanism of PNAP photosensitization has been investigated by testing the efficiency of singlet oxygen production using photooxidation of 2,2,6,6-tetramethylpiperidine (TEMP) and photodegradation of guanosine. In both the cases, the enhancement effect of deuterated solvents has been observed. Results of these experiments suggest the significant role of type II mechanisms in PNAP photosensitization.


Subject(s)
Acetophenones/chemistry , Cyclic N-Oxides/radiation effects , Electron Spin Resonance Spectroscopy , Guanosine/radiation effects , Oxygen/radiation effects , Photochemistry , Radiation-Sensitizing Agents/chemistry , Singlet Oxygen , Spectrophotometry, Ultraviolet , Spin Labels
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