ABSTRACT
Papular-purpuric gloves and socks syndrome is a rare, highly contagious dermatosis caused by parvovirus B19, which may result in the abrupt cessation of red blood cell production in patients with preexisting hematological diseases. It affects predominantly children and young adults and has an unusual presentation.
A síndrome "gloves and socks" pápulo-purpúrica é uma dermatose incomum, altamente contagiosa, causada pelo parvovírus B19, que pode provocar interrupção aguda da produção de glóbulos vermelhos em pacientes com doenças hematológicas preexistentes. Acomete, principalmente, crianças e jovens, e tem uma apresentaçao nao-usual.
Subject(s)
Humans , Female , Adult , Purpura/virology , Parvovirus B19, Human , Skin Diseases, Viral/virology , Parvoviridae Infections/complications , Foot Dermatoses/virology , Hand Dermatoses/virology , Purpura/diagnosis , SyndromeABSTRACT
Two atypical cases of parvovirus B19 infection occurred consecutively within a family. A 14 year-old patient presented an extended papular-purpuric "gloves and socks" syndrome and two weeks later his mother developed a predominantly unilateral purpuric rash in the limbs with severe malaise. Specific IgM antibodies in the boy and polymerase chain reaction (PCR) and serology in the mother, confirmed parvovirus B19 infection. We emphasize the variable presentation of B19 infection within a family. The importance ofetiologic studies in the presence of atypical exanthemas and the utility of PCR in the diagnosis ofB19 are undesrscored.
Subject(s)
Adolescent , Adult , Female , Humans , Male , Erythema Infectiosum/diagnosis , Exanthema/diagnosis , Foot Dermatoses/virology , Hand Dermatoses/virology , Purpura/diagnosis , Erythema Infectiosum/virology , Exanthema/virology , Family , Foot Dermatoses/pathology , Hand Dermatoses/pathology , /genetics , Polymerase Chain Reaction , Purpura/virology , SyndromeSubject(s)
Humans , Male , Female , Infant , Hand Dermatoses/diagnosis , Herpes Simplex/diagnosis , Acyclovir/therapeutic use , Antiviral Agents/therapeutic use , Hand Dermatoses/drug therapy , Hand Dermatoses/virology , Herpes Simplex/drug therapy , Herpes Simplex/virology , Herpesvirus 1, Human/isolation & purification , Polymerase Chain ReactionABSTRACT
Papular-purpuric "gloves and socks" syndrome (PPGSS) is a novel, rare, self-limiting dermatosis caused by human parvovirus B19. It consists of pruritic edema and erythema of the hands and feet in a gloves-and-socks distribution, and it is associated with oral lesions and fever. We present a case of PPGSS in a 22-year-old Brazilian woman. Clinical and laboratory evaluation, including serological tests, PCR and gene sequencing, confirmed the presence of human parvovirus B19.
Subject(s)
Adult , Female , Humans , Erythema Infectiosum/virology , Foot Dermatoses/virology , Hand Dermatoses/virology , /isolation & purification , Purpura/virology , DNA, Viral , Enzyme-Linked Immunosorbent Assay , Erythema Infectiosum/diagnosis , Foot Dermatoses/diagnosis , Hand Dermatoses/diagnosis , Phylogeny , Polymerase Chain Reaction , /genetics , Purpura/diagnosis , SyndromeABSTRACT
Presentamos, a propósito de un caso clínico de "Enfermedad en guante y calcetín", una revisión acabada y actualizada del parvovirus B19, agente causal de un amplio rango de enfermedades cutáneas, como: eritema infeccioso, exantemas morbiliformes, vesiculares y purpúricos, enfermedad de Kawasaki y otras.
Subject(s)
Humans , Adult , Female , Hand Dermatoses/virology , Foot Dermatoses/virology , Erythema Infectiosum/virology , /pathogenicityABSTRACT
We present a case of papular-purpuric "gloves and socks" syndrome (PPGSS) in an adult male with acute parvovirus B19 infection. The patient displayed the classical features of fever, oral lesions, and purpura on hands and feet, but the purpuric lesions on the feet evolved to superficial skin necrosis, a feature not previously described in this syndrome. We believe this is the first reported case of PPGSS occurring in Brazil