ABSTRACT
Congenital heart defect (CHD) is common in infants with Down syndrome (DS), which is the principle cause of mortality. However, there is no data available for the frequency and types of CHD in infants with DS in Korea. We investigated the frequency of CHD in infants with DS in Korea. After the survey on birth defects was conducted throughout the country, the prevalence of CHD in DS in 2005-2006 was calculated. This study was conducted based on the medical insurance claims database of the National Health Insurance Corporation. The number of total births in Korea was 888,263 in 2005-2006; of them, 25,975 cases of birth defects were identified. The prevalence of DS was 4.4 per 10,000 total births, accounting for 1.5% of all birth defects. Of the 394 infants with DS, 224 (56.9%) had a CHD. Atrial septal defect was the most common defect accounting for 30.5% of DS followed by ventricular septal defect (19.3%), patent duct arteriosus (17.5%), and atrioventricular septal defect (9.4%). Our study will be helpful to demonstrate the current status of DS and to identify the distribution of CHD in infants with DS in Korea.
Subject(s)
Adult , Female , Humans , Male , Asian People , Birth Weight , Chromosome Aberrations , Databases, Factual , Down Syndrome/complications , Ductus Arteriosus, Patent/epidemiology , Gestational Age , Heart Defects, Congenital/epidemiology , Heart Septal Defects/epidemiology , Heart Septal Defects, Atrial/epidemiology , Heart Septal Defects, Ventricular/epidemiology , Prevalence , Republic of Korea/epidemiologyABSTRACT
A retrospective analysis of 3790 consecutive patients with congenital heart disease (CHD) who underwent haemodynamic and angiographic studies at Sri Jayadeva Institute of Cardiology, Bangalore, from April 1981 to April 1994 has been done. The incidence of various CHD has been compared with that in other series from Asian and Western countries. Out of 6985 patients who underwent haemodynamic studies, 3790 had CHD (54.3%). Approximately 63 percent (2386) of these cases had shunt lesions like atrial septal defect (ASD), ventricular septal defect (VSD) and patent ductus arteriosus (PDA). Among them, 15 percent (367) had pulmonary arterial hypertension of various grades. The overall incidence of pulmonary arterial hypertension is higher than that reported in the Western literature. Corrective surgery was done in approximately 63 percent of cases. Ethnic differences in the incidence of CHD were found in this study when compared to the Eastern and Western literature. Congenital aortic stenosis and coarctation of aorta were less common compared to Western countries and Tetralogy of Fallot was less common compared to Eastern countries.
Subject(s)
Adolescent , Adult , Aged , Asia/epidemiology , Child , Child, Preschool , Europe/epidemiology , Female , Cardiac Catheterization , Heart Defects, Congenital/diagnosis , Heart Septal Defects/epidemiology , Humans , India/epidemiology , Infant , Male , Middle Aged , North America/epidemiology , Retrospective StudiesABSTRACT
A total of 2,764 students were examined from five schools in Bang Pa-in, district, Ayutthaya Province, Thailand; 12 were found to have heart disease, a prevalence of 4.34 per thousand examined. Of these 4 cases were known by their parents to have heart disease prior to our study. The prevalence of congenital heart disease was 3.3 and of rheumatic heart disease 1 per thousand students. The incidence of functional heart murmur was 46%. The prevalence rate of heart disease in Thai school children was similar to rates in reports from Canada, America and Iran.