ABSTRACT
Hematopoietic stem cell transplantation is the accepted therapy of choice for a variety of malignant and non-malignant diseases in children and adults. Initially developed as rescue therapy for a patient with cancer after high doses of chemotherapy and radiation as well as the correction of severe deficiencies in the hematopoietic system, it has evolved into an adoptive immune therapy for malignancies and autoimmune disorders. The procedure has helped to obtain key information about the bone marrow environment, the biology of hematopoietic stem cells and histocompatibility. The development of this new discipline has allowed numerous groups working around the world to cure patients of diseases previously considered lethal. Together with the ever growing list of volunteer donors and umbilical cord blood banks, this has resulted in life saving therapy for thousands of patients yearly. We present an overview of the procedure from its cradle to the most novel applications, as well as the results of the HSC transplant program developed at our institution since 1989.
Subject(s)
History, 20th Century , History, 21st Century , Humans , Hematopoietic Stem Cell Transplantation , Tissue Donors/statistics & numerical data , Hematopoietic Stem Cell Transplantation/history , Hematopoietic Stem Cell Transplantation/statistics & numerical data , Hematopoietic Stem Cell Transplantation/trends , Transplantation Conditioning , Transplantation, Autologous , Transplantation, Homologous , Tissue Donors/supply & distribution , Tissue and Organ Procurement/statistics & numerical dataSubject(s)
Animals , History, 19th Century , History, 20th Century , Humans , Mice , Hematopoietic Stem Cell Transplantation/history , Academies and Institutes , Anemia, Aplastic/surgery , Bone Marrow Transplantation/history , Cord Blood Stem Cell Transplantation/history , Hospitals, Public , Hematologic Neoplasms/surgery , Hematopoietic Stem Cell Transplantation/methods , Hematopoietic Stem Cell Transplantation/trends , Mexico , Models, Animal , Radiation Chimera , Transplantation, Homologous , United StatesABSTRACT
El traspalnte de células progenitoras hematopoyéticas, consiste en la infusión de estas células obtenidas de la médula ósea, la sangre periférica, el cordón umbilical o el hígado fetal, a un paciente que ha sido previamente acondicionado para recibir el injerto. Este proceder se ha convertido en una modalidad terapéutica para una gran variedad de enfermedades, como hemopatías malignas, anemia aplástica, inmunodeficiencias y gran número de tumores sólidos. En la actualidad se trasplantan más de 30 000 pacientes al año en todo el mundo. La selección de la fuente y el tipo de trasplante están determinados por diferentes factores. Se lleva a cabo una revisión de algunos aspectos básicos del trasplante de células hematopoyéticas como su historia, tipos, fuentes, e indicaciones