ABSTRACT
El carcinoma renal con diferenciación sarcomatoide es una entidad rara con muy pocos casos reportados en la literatura. Se presenta un caso de un paciente masculino de 65 años que por historia de hematuria macroscópica, se le realizan estudios diagnósticos, reportándose masa renal izquierda, efectuándos ele nefrectomía radical cuyo resultado de patología fue un carcinoma de células claras. Tres meses después de la cirugía el paciente refiere dolor localizado en el mismo sitio anatómico por lo que se le realiza tomografía, reportándose masa a nivel del retroperitoneo, debido a este hallazgo se decide efectuar tumorectomía, en la que se reporta sarcoma fusocelular de alto grado. Los resultados patológicos no corresponden a dos entidades patológicas diferentes, sino al mismo origen tumoral, con progresión de la enfermedad.
Sarcomatoid diferentaton in renal cell carcinoma is a rare disease with very few cases reported in the literature. A 65 year old man with hematuria anda lef renal mass underwent radical nephrectomy. Pathology reported a clear renal cell carcinoma. Three months afer surgery, the patent presentedwith abdominal complaints and a CT scan of the abdomen revealing fndings consistent with a retroperitoneal mass. The patent underwent a secondsurgical resecton and pathology revealed a high grade spindle cell sarcoma. The two diferent pathology reports are not two diferent pathologies; sarcomatoid diferentaton in renal cell carcinoma represents a common pathway of de-diferentaton of renal tumors.
Subject(s)
Male , Carcinoma, Renal Cell/pathology , Hematuria/complications , Hematuria/physiopathology , Nephrectomy/adverse effects , Kidney Neoplasms/surgeryABSTRACT
Hepatitis B virus (HBV)-associated glomerulonephropathy (HBV-GN) has been increasingly reported, especially in adults. In the present study, the authors investigated the clinical and histopathology features of patients who suspected HBV-GN in 24 patients and age ranging from 23 to 74 years (mean 43 years). Asymptomatic hematuria was the most common presentation (54%); followed by edema and hypertension at equal percentages of 50%. The nephrotic syndrome was presented in 43%, the nephrito-nephrotic syndrome in 3.5%. Clinically suspected rapidly progressive GN was found in 14%. Renal insufficiency was determined in 30%. The most common pathologic finding was IgA nephropathy (IgAN 29%), followed by membranous nephropathy (21%), focal segmental glomerulo sclerosis (FSGS 11%), membranoproliferative GN (11%), post-infectious GN (11%). Liver disease activity also tended to be mild or had no symptoms of hepatitis. The authors remission rates both complete and partial were 75% (higher than the usual report), notwithstanding treatment. The authors achieved a sustained complete remission in half of the patients (3 in 6 cases) treated with steroid alone and 2 out of 7 cases (28.6%) treated with anti-viral therapy. Spontaneous remission was demonstrated in 2 (1 with IgAN + FSGS, and 1 with post infectious GN) out of 6 patients (33.3%). None of the patients in both treatment groups turned to ESRD that occurred in 2 cases receiving non-specific treatment. Of note, all of the patients who received anti-viral therapy or corticosteroid and had complete follow up were in remission either complete or partial.
Subject(s)
Adult , Aged , Antiviral Agents/therapeutic use , Biopsy , Female , Glomerulonephritis/drug therapy , Glucocorticoids/therapeutic use , Hematuria/physiopathology , Hepatitis B/complications , Humans , Male , Middle Aged , Nephrotic Syndrome/drug therapy , Prednisolone/therapeutic use , Renal Insufficiency/drug therapy , ThailandABSTRACT
The carcinogenicity of bracken fern harvest from two regions of Paraná State to induce hematury in rats was studied. In order to do that, 33 Wistar rats were divided in three groups. Groups I and II received an aqueous extract of bracken fern from Londrina-PR or Ibaiti-PR, respectively, in drinking water for 60 days. Group III, control group, received regular plain water with no bracken fern. After 15 months, euthanasia was performed in all animals and samples were collected for histology examination. Histologic analysis revealed that two animals of Group II had ileal adenocarcinoma and soft tissue fibroma of leg.
Subject(s)
Animals , Male , Female , Plant Shoots/toxicity , Hematuria/physiopathology , Neoplasms/physiopathology , Plant Poisoning , Pteridium/toxicity , Rats/anatomy & histologyABSTRACT
Objetivo: descrever um caso de hipercalciúria associada a hematúria microscópica que teve disúria como queixa inicial. Descrição: escolar de 5 anos procurou o serviço de emergência com queixa de disúria. Os exames laboratoriais iniciais revelaram a presença de hematúria microscópica persistente e, durante a investigação ambulatorial, confirmara-se os diagnósticos / Objective: to report a case of hypercalciuria associated to microscopic hematuria in which dysuria was the initial complaint. Description: a five-year-old child sought the pediatric emercy service with dysuria. Initial laboratory exams revealed microscopic hematuria and the child was referred to the outpatient clinic, where the diagnosis of idiopathic hypercalciuria associated to hyperuricosuria was confirmed..
Subject(s)
Humans , Male , Child, Preschool , Kidney Calculi/pathology , Calcium Metabolism Disorders/physiopathology , Hematuria/physiopathology , ChildABSTRACT
Las fístulas renales congénitas son trastornos raros. Su característica clínica mas importante es la hematuria macroscópica. La arteriografía renal es el mejor estudio para su diagnóstico. La embolización arterial es un buen procedimiento para tratar definitivamente estas lesiones en forma conservadora. Se presenta un caso de fístula arteriovenosa renal congénita tratada con buenos resultados mediante embolización supraselectiva, y se revisa la literatura