ABSTRACT
Duzentos e cinquenta e dois candidatos a doadores de sangue HBsAg positivos (media de idade= 32,6 anos, 97,7masculino) foram investigados num estudo transversal para determinar suas caracteristicas clinicas, laboratoriais e histologicas. Foi tambem comparada a positividade e a negatividade dos marcadores sorologicos HBeAg, anti-HBe e IgM anti-HBc com os valores das aminotransferases sericas...
Subject(s)
Humans , Male , Adolescent , Adult , Middle Aged , Blood Donors , Hepatitis B/blood , Serologic Tests/methods , Hepatitis B Antibodies/immunology , Hepatitis B/immunology , Hepatitis B/parasitology , Biomarkers , Demography , Risk Factors , Transaminases/analysis , Transaminases/immunologyABSTRACT
A clinical study on the evolution of patients with schistosomiasis mansoni conducted since 1983 at the outpatient clinic of the Infectious and Parasitic Disease Service in the Clementino Fraga Filho University Hospital in Rio de Janeiro, Brazil, comparing prevalence of positive tests for HBsAg, anti-HBsAg, and anti-HBc among patients infected with Schistosoma mansoni coming from various regions of Brazil and with different clinical forms of the disease. A non-significant predominance of HBsAg, anti-HBsAg, and anti-HBc was detected among patients with the hepatosplenic form of schistosomiasis, who presented a more severe clinical evolution with a higher frequency of hematemesis and/or melena, in addition to the development of macronodular cirrohosis and a worse prognosis as compared to patients with the toxemic form, schistosomiasis-infection and the hepatointestinal form.
Subject(s)
Humans , Hepatitis B virus , Hepatitis B/parasitology , Schistosomiasis mansoni/complications , BrazilABSTRACT
Sera from one hundred and fifty three chronic Fasciola cases were screened for the presence of HB markers [HBsAg, anti HBc and anti HBs] and anti HCV using ELISA technique. Quantitative stool examination and estimation of liver enzymes [AST-ALT-bilirubin] levels of the study population were performed. HBsAg was present in 5 [3.3%], anti HBs in 13 [8.5%], HBexposed [HBex] in 44 [28.8%] and anti HCV in 13 [8.5%] of examined sera. HBV and HCV markers were significantly higher among older age groups. Concerning familial aggregation of hepatitis markers, 7 [15.9%] of the 44 HBex cases had two individuals per family who had evidence of exposure to HBV. No significant change in Fasciola GMEC and liver function tests have been noticed