Polymorphisms of High-Affinity IgE Receptor and Histamine-Related Genes in Patients with ASA-Induced Urticaria/Angioedema

The pathogenic mechanism of ASA-induced urticaria/angioedema (AIU) is still poorly understood, but it has been known that histamine releasing by cutaneous mast cell activation is considered to be an important role. Considering the importance of histamine in AIU, we speculated that a genetic abnormality of histamine-related genes such as a high-affinity IgE receptor, a metabolic enzyme of histamines and histamine receptors, may be involved in the development of AIU. Enrolled in the study were 110 patients with AIU, 53 patients without ASA hypersensitivity who had various drug allergies presenting as exanthematous skin symptoms, and 99 normal healthy controls (NC). Eleven single nucleotide polymorphisms (SNPs) of the beta chain of the high-affinity IgE receptor (FCER1B) and three histamine-related genes-histamine N-methyltransferase (HNMT), histamine H1 receptor (HRH1), histamine H2 receptor (HRH2)-were screened using the SNP-IT assay based on a single base extension method. No significant differences were observed in allele and genotype frequencies, and haplotype frequencies of all the SNPs of FCER1B, HNMT, HRH1, and HRH2 among the three groups (p>0.05, respectively). These results suggest that the polymorphisms of FCER1B and the three histamine-related genes may not contribute to the development of AIU phenotype in the Korean population.

Evaluacion de la liberacion de Histamina para el diagnostico de alergia y farmacos mediante un metodo inmunoenzimatico competitivo (ELISA), en poblacion aparentemente sana y poblacion alergica / Evaluation of the liberation of Histamina for I diagnose of allergy to farmacos, by means of metodo inmunoenzimatico competitive (ELISA), in population apparently it heals and alergica population

La alergia a fármacos es un problema importante en salud pública, que día a día tiene mayor. repercusión en nuestra población. Lamentablemente en nuestro medio no se le otorga la debida importancia; por lo que no contamos con fuentes de referencia sobre la incidencia y las consecuencias de esta patología. Esta realidad, también la falta de procedimientos para un diagnostico correcto y de verdadero beneficio para las personas alérgicas, que permitan la identificación de él o los fármacos que potencialmente podrían causar reacciones nocivas y así permitir el uso de medicamentos sin el temor de ocasionar una reacción adversa. En este sentido, pretendimos adecuar una nueva prueba de laboratorio destinada a evaluar la liberación de histamina como una alternativa diagnóstica que sea precisa y que oriente a tomar las acciones más adecuadas en el caso de pacientes con sospecha cíe alergia