ABSTRACT
The technique of liquisolid preparations was used to formulate hydrochlorothiazide, a model drug, in tablet form. Drug solution in peg200 was blended with different common tablet excipients such as Avicel, Aerosil, Calcium phosphate, Magnesium oxide, and Magnesium carbonate. The drug admixtures were directly compressed into tablets. The dissolution rates of the liquisolid tablets were determined according to USP basket method. The obtained dissolution profiles were compared to that of a reference tablet, made by simple trituration of drug powder with avicel, and a commercial product. The results showed that, generally, liquisolid tablets present a significantly higher dissolution rate. A