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Indian Pediatr ; 2009 June; 46(6): 525-527
Article in English | IMSEAR | ID: sea-144063

ABSTRACT

We report a case of chronic eosinophilic leukemia in a 9 year old girl who presented with anemia, thrombocytopenia, leucocytosis (mostly dysplastic eosinophils), lymphadenopathy and hepatosplenomegaly. There was no increase in blasts but myelofibrosis was seen in the bone marrow. A previously unreported translocation 46,XX,t(1;4)(q24;q35), was found on cytogenetic analysis and involvement of the myocardium was also present. Shortly after commencing steroids, the family abandoned therapy.


Subject(s)
Cardiomyopathies/blood , Cardiomyopathies/diagnosis , Cardiomyopathies/drug therapy , Cardiomyopathies/genetics , Child , Chronic Disease , Echocardiography , Eosinophils , Female , Glucocorticoids/therapeutic use , Humans , Hypereosinophilic Syndrome/blood , Hypereosinophilic Syndrome/diagnosis , Hypereosinophilic Syndrome/drug therapy , Hypereosinophilic Syndrome/genetics , Translocation, Genetic
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