Cortical hyperostosis following long-term therapy administration of prostaglandin therapy in infants with ductus dependent congenital heart disease

Prostaglandin has been used in infants with ductus dependent cyanotic congenital heart disease until surgery can be performed. One of the complications of prolonged therapy is periostitis, cortical hyperostosis usually simmetrical resembling Caffey's disease. A case with discussion is presented.