Linfadenopatía angioinmunoblástica: fisiopatología, citogenética, histología y tratamiento / Angioimmunoblastic lymphadenopathy: physiopathology, cytogenetic, histology and treatment

La linfadenopatía angioinmunoblástica, a pesar de ser clínicamente similar a la enfermedad de Hodking, es una entidad hiperinmune distinta, aparentemente de linfocitos B. Es una enfermedad caracterizada por síntomas constitucionales y linfadenopatía. El diagnóstico se establece mediante biopsia del ganglio linfático, con la cual se observan alteraciones en la morfología del mismo, ausencia de centros germinativos, arborización de vénulas poscapilares y un infiltrado polimorfo que incluye inmunoblastos. Los hallazgos de laboratorio incluyen, anemia hemolítica autoinmune e hipergammaglobulinemia policlonal

Hypersensitivity reaction to carbamazepine presenting with angioimmunoblastic lymphadenopathy generalized dermatitis and bone marrow granulomas

A 29-year-old Saudi woman was admitted to the medical unit at King Khalid University Hospital with a history of generalized erythematous and vesicular skin rash, lymphadenopathy and hepatosplenomegaly. She was a known epileptic receiving carbamazepine treatment for the last 2 years. The lymph node biopsy showed features of angioimmunoblastic lymphadenopathy. The bone marrow trephine biopsy revealed the presence of small non-caseating epitheloid granulomas and her skin showed features of exfoliative and vesicular dermatitis. The histological features are described and discussed in addition to a detailed review of the literature and a comparison with other reported cases is made