ABSTRACT
Evaluation of puberty parameters in renal transplant girls who receiving a combination of immunosuppressive treatment including cyclosporine A, prednisolone and azathiopnne 18 living related donor renal transplant girls were evaluated initially and followed for 2 years post transplant. All underwent measurement of Tanner stage, height, bone age,and endocrinologic evaluation. Our results showed that at initial evaluation retarded sexual maturation was observed in 22.2% of girls and height SDS in 38.9% of girls were greater than 2 SD below the mean for age. Serum estradiol level was significantly correlated with height,bone age, and Tanner stage. The height increment was significantly correlated inversely with the duration of immunosuppresion. Dialysis duration was significantly longer in girls with good physical growth followed transplantation. Our data indicate that diminished renal function and predinsolone treatment appear to be additive in delaying maturation in some girls after kidney transplantation. Moreover, renal transplant girls maintained on triple immunosupperssive treatment showed acceptable puberty parameters in the majority of patients